Art

J-GLOBAL ID：201902225520464057   Reference number：19A1532024

The Effects of Clioquinol on P-glycoprotein Expression and Biometal Distribution in the Mouse Brain Microvasculature

マウス脳微小血管系におけるP糖蛋白質発現と生体金属分布に及ぼすクリオキノールの影響【JST・京大機械翻訳】

Author (6)： McInerney Mitchell P. (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia) ,  Pan Yijun (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia) ,  Volitakis Irene (The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia) ,  Bush Ashley I. (The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia) ,  Short Jennifer L. (Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia) ,  Nicolazzo Joseph A. (Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia)
Material： Journal of Pharmaceutical Sciences  (J Pharm Sci)
Volume： 108  Issue： 7  Page： 2247-2255  Publication year： 2019 
JST Material Number： C0260B  ISSN： 0022-3549  CODEN： JPMSAE  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Previous studies have demonstr...

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Thesaurus term： iron ,  cortex(animal tissue) ,  potassium ,  zinc ,  magnesium ,  amyloid beta-protein ,  human(primates) ,  *mouse(animal) ,  in vitro experiment ,  plasma(blood) ,  oral administration ,  ionophore ,  blood-brain barrier ,  redistribution ,  nitrogen heterocyclic compound ,  phenolic compound ,  aromatic chlorine compound ,  aromatic iodine compound ,  polynuclear aromatic compound

Author keywords (5)： ABC transporter(s) ,  blood-brain barrier (BBB) ,  central nervous system ,  efflux pump(s) ,  P-glycoprotein

JST classification (1)： Basic biopharmacy  (GY01021U)

Substance index (1)： Clioquinol

Terms in the title (8)： マウス ,  脳 ,  微小血管系 ,  P糖蛋白質 ,  発現 ,  生体 ,  分布 ,  クリオキノール