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J-GLOBAL ID：201902226201107250   Reference number：19A0980885

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

CRISPR-Cas9を介するHLA遺伝子の標的化破壊は免疫適合性を増強したIPSCを生成する【JST・京大機械翻訳】

Author (20)： Xu Huaigeng (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Wang Bo (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Ono Miyuki (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Ono Miyuki (Core Center for iPS Cell Research, Research Center Network for Realization of Regenerative Medicine, Japan Agency for Medical Research and Development (AMED), Tokyo, Japan) ,  Kagita Akihiro (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Fujii Kaho (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Sasakawa Noriko (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Sasakawa Noriko (Core Center for iPS Cell Research, Research Center Network for Realization of Regenerative Medicine, Japan Agency for Medical Research and Development (AMED), Tokyo, Japan) ,  Ueda Tatsuki (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Gee Peter (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Gee Peter (Core Center for iPS Cell Research, Research Center Network for Realization of Regenerative Medicine, Japan Agency for Medical Research and Development (AMED), Tokyo, Japan) ,  Nishikawa Misato (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Nomura Masaki (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Kitaoka Fumiyo (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Takahashi Tomoko (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Okita Keisuke (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Yoshida Yoshinori (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Kaneko Shin (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Hotta Akitsu (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan) ,  Hotta Akitsu (Core Center for iPS Cell Research, Research Center Network for Realization of Regenerative Medicine, Japan Agency for Medical Research and Development (AMED), Tokyo, Japan)
Material： Cell Stem Cell
Volume： 24  Issue： 4  Page： 566-578.e7  Publication year： 2019 
JST Material Number： W3106A  ISSN： 1934-5909  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Induced pluripotent stem cells...

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Thesaurus term： antigen presentation ,  T cell ,  donor ,  induced pluripotent stem cell ,  editing ,  *adaptability ,  *gene ,  *targeting ,  shake out ,  antigen ,  allele ,  HLA-A ,  regenerative medicine
Semi thesaurus term： ホモ接合 ,  *Cas9 , 【Automatic Indexing@JST】

Author keywords (10)： iPS cell ,  genome editing ,  CRISPR-Cas9 ,  HLA ,  immune rejection ,  B2M ,  CIITA ,  allogenic ,  KIR ,  NK cell

JST classification (5)： Immunotherapy for tumors  (GE03035B) ,  Bioenergetics in general  (EB10010X) ,  Vasculature  (EJ04030O) ,  Development(=generation)and differentiation  (EJ16020W) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Terms in the title (8)： CRISPR-Cas9 ,  HLA遺伝子 ,  標的化 ,  破壊 ,  免疫 ,  適合性 ,  増強 ,  IPSC