Art

J-GLOBAL ID：201902226532595375   Reference number：19A0313475

Elevated Membrane Cholesterol Disrupts Lysosomal Degradation to Induce β-Amyloid Accumulation The Potential Mechanism Underlying Augmentation of β-Amyloid Pathology by Type 2 Diabetes Mellitus

膜コレステロールの上昇は2型糖尿病によるβアミロイド病理の増強の基礎となる潜在的機序を誘導するためにリソソーム分解を破壊する【JST・京大機械翻訳】

Author (6)： Takeuchi Shingo (Section of Cell Biology and Pathology, Department of Alzheimer’s Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Ueda Naoya (Section of Cell Biology and Pathology, Department of Alzheimer’s Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Suzuki Keiko (Section of Cell Biology and Pathology, Department of Alzheimer’s Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Shimozawa Nobuhiro (Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan) ,  Yasutomi Yasuhiro (Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan) ,  Kimura Nobuyuki (Section of Cell Biology and Pathology, Department of Alzheimer’s Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan)
Material： American Journal of Pathology  (Am J Pathol)
Volume： 189  Issue： 2  Page： 391-404  Publication year： 2019 
JST Material Number： E0065B  ISSN： 0002-9440  CODEN： AJPAA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The endocytic membrane traffic...

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Thesaurus term： pathogenesis ,  in vitro experiment ,  *amyloid beta-protein ,  Macaca fascicularis ,  *type 2 diabetes mellitus ,  endocytosis ,  membrane transport ,  Alzheimer disease ,  human(primates) ,  *pathological state ,  risk factor ,  sterol ,  alicyclic alcohol
Semi thesaurus term： コレステロール代謝 ,  動物モデル ,  発症 , 【Automatic Indexing@JST】

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Nervous system diseases  (GN03000O)

Substance index (1)： Cholesterol

Terms in the title (9)： コレステロール ,  2型糖尿病 ,  βアミロイド ,  病理 ,  増強 ,  基礎 ,  誘導 ,  リソソーム分解 ,  破壊