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J-GLOBAL ID：201902226829877713   Reference number：19A0359522

T cell-intrinsic prostaglandin E₂-EP2/EP4 signaling is critical in pathogenic T_H17 cell-driven inflammation

T細胞固有プロスタグランジンE2-EP2/EP4シグナル伝達は病原性T_H17細胞駆動炎症において重要である【JST・京大機械翻訳】

Author (10)： Lee Jinju (Core Research for Evolutional Science and Technology (CREST), Medical Innovation Center, Kyoto, Japan) ,  Lee Jinju (Kyoto University, Graduate School of Biostudies, Kyoto, Japan) ,  Aoki Tomohiro (Core Research for Evolutional Science and Technology (CREST), Medical Innovation Center, Kyoto, Japan) ,  Aoki Tomohiro (Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Thumkeo Dean (Core Research for Evolutional Science and Technology (CREST), Medical Innovation Center, Kyoto, Japan) ,  Thumkeo Dean (Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Siriwach Ratklao (Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Yao Chengcan (Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom) ,  Narumiya Shuh (Core Research for Evolutional Science and Technology (CREST), Medical Innovation Center, Kyoto, Japan) ,  Narumiya Shuh (Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Kyoto, Japan)
Material： Journal of Allergy and Clinical Immunology  (J Allergy Clin Immunol)
Volume： 143  Issue： 2  Page： 631-643  Publication year： 2019 
JST Material Number： A0182B  ISSN： 0091-6749  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： IL-23 is the key cytokine for ...

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Thesaurus term： *cellular signal transduction ,  mouse(animal) ,  psoriasis ,  *T cell ,  pathogenesis ,  cytokine ,  *prostaglandin ,  pathological state ,  human(primates) ,  gene ,  autoimmune disease
Semi thesaurus term： *EP2 ,  *EP4 ,  インターロイキン17 ,  インターロイキン23 , 【Automatic Indexing@JST】

Author keywords (9)： Psoriasis ,  pathogenic T_H17 cells ,  IL-23 receptor ,  prostaglandin E₂ ,  prostaglandin E receptor EP2 ,  prostaglandin E receptor EP4 ,  signal transducer and activator of transcription 3 ,  cAMP-responsive element binding protein 1 ,  nuclear factor κ light chain enhancer of activated B cells

JST classification (2)： Immunological reaction in general  (ED03010T) ,  Leukocytes,lymphocytes  (EJ03030H)

Terms in the title (9)： T細胞 ,  固有 ,  プロスタグランジンE2 ,  EP2 ,  EP4 ,  シグナル伝達 ,  病原性 ,  細胞 ,  炎症