Art

J-GLOBAL ID：201902227305405687   Reference number：19A1880378

Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine

p2テトラヒドロフラニルグリシンによるアロフェニルノルスタチン系ペプチド模倣体からのロピナビルおよびダルナビル耐性ウイルスに対する強力なヒト免疫不全ウイルス1型プロテアーゼ阻害剤の同定【JST・京大機械翻訳】

Author (12)： Hidaka Koushi (Laboratory of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Japan) ,  Kimura Tooru (Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan) ,  Sankaranarayanan Rajesh (Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan) ,  Wang Jun (Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan) ,  McDaniel Keith F. (Global Pharmaceutical Research and Development, AbbVie, Illinois, United States) ,  Kempf Dale J. (Global Pharmaceutical Research and Development, AbbVie, Illinois, United States) ,  Kameoka Masanori (Department of International Health, Kobe University Graduate School of Health Sciences, Japan) ,  Adachi Motoyasu (Quantum Beam Science Drectorate, National Institutes for Quantum and Radiological Science and Technology, Ibaraki, Japan) ,  Kuroki Ryota (Quantum Beam Science Center, Japan Atomic Energy Agency, Ibaraki, Japan) ,  Nguyen Jeffrey-Tri (Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan) ,  Hayashi Yoshio (Department of Medicinal Chemistry, Tokyo University of Pharmacy and Life Sciences, Japan) ,  Kiso Yoshiaki (Laboratory of Peptide Sciences, Nagahama Institute of Bio-Science and Technology, Japan)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 61  Issue： 12  Page： 5138-5153  Publication year： 2018 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The emergence of drug-resistan...

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Thesaurus term： multiple drug resistance ,  drug therapy ,  *peptide bond hydrolase ,  *proteinase inhibitor ,  wild type ,  hydrogen bond ,  *HIV1 ,  co-crystal ,  virus resistance ,  *resistant virus ,  *microorganism ,  *animal virus
Semi thesaurus term： 残基 ,  *阻害剤 , 【Automatic Indexing@JST】

JST classification (2)： Peptides  (CF10080G) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (3)： Darunavir ,  Lopinavir ,  Allophenylnorstatine

Terms in the title (8)： アロフェニルノルスタチン ,  ペプチド模倣体 ,  ロピナビル ,  ダルナビル ,  耐性ウイルス ,  ヒト免疫不全ウイルス1型 ,  プロテアーゼ阻害剤 ,  同定