Art

J-GLOBAL ID：201902227392923436   Reference number：19A1328473

An Openable Artificial Intestinal Tract System Enables the Evaluation of Drug Absorption in Caco-2 Cells through the Reduction in Thickness of the Unstirred Water Layer

開放可能な人工腸管系は,非撹拌水層の厚さの減少を通してCaco-2細胞における薬物吸収の評価を可能にする

Author (7)： Kono Yusuke (Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University) ,  Kono Yusuke (Ritsumeikan-Global Innovation Research Organization, Ritsumeikan University) ,  Konishi Satoshi (Ritsumeikan-Global Innovation Research Organization, Ritsumeikan University) ,  Konishi Satoshi (Department of Mechanical Engineering, Ritsumeikan University) ,  Konishi Satoshi (Graduate School of Science and Engineering, Ritsumeikan University) ,  Fujita Takuya (Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University) ,  Fujita Takuya (Ritsumeikan-Global Innovation Research Organization, Ritsumeikan University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 5  Page： 840-844(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Caco2 cell ,...
Semi thesaurus term： *人工腸管 ,...

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Author keywords (8)： drug absorption ,  artificial intestinal tract ,  unstirred water layer ,  Caco-2 cell ,  drug absorption ,  artificial intestinal tract ,  unstirred water layer ,  Caco-2 cell

JST classification (3)： Basic medicine on digestive system  (GH01020E) ,  Basic biopharmacy  (GY01021U) ,  Biological system models in general  (EL02010K)

Substance index (4)： Imipramine ,  Chlorpromazine ,  Mesalazine ,  Clonidine

Reference (18)：

• 1) Volpe DA. Variability in Caco-2 and MDCK cell-based intestinal permeability assays. J. Pharm. Sci., 97, 712-725 (2008).
• 2) Bittermann K, Goss KU. Predicting apparent passive permeability of Caco-2 and MDCK cell-monolayers: a mechanistic model. PLOS ONE, 12, e0190319 (2017).
• 3) Ingels FM, Augustijns PF. Biological, pharmaceutical, and analytical considerations with respect to the transport media used in the absorption screening system, Caco-2. J. Pharm. Sci., 92, 1545-1558 (2003).
• 4) Sun D, Lennernas H, Welage LS, Barnett JL, Landowski CP, Foster D, Fleisher D, Lee KD, Amidon GL. Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs. Pharm. Res., 19, 1400-1416 (2002).
• 5) Marino AM, Yarde M, Patel H, Chong S, Balimane PV. Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds. Int. J. Pharm., 297, 235-241 (2005).

Terms in the title (8)： 人工 ,  腸管 ,  撹拌 ,  水層 ,  厚さ ,  Caco-2細胞 ,  薬物吸収 ,  評価