Art

J-GLOBAL ID：201902227531165894   Reference number：19A2120437

Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels

ヒト肝細胞癌細胞におけるMPV17様蛋白質(M-LPH)遺伝子のノックアウトは蛋白質レベルでのTFAM,OGG1およびLIG3の減少を介してmtDNA完全性の障害をもたらす【JST・京大機械翻訳】

Author (5)： Iida Reiko (Division of Life Science, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan) ,  Iida Reiko (Organization for Life Science Advancement Programs, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan) ,  Ueki Misuzu (Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan) ,  Yasuda Toshihiro (Organization for Life Science Advancement Programs, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan) ,  Yasuda Toshihiro (Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan)
Material： Oxidative Medicine and Cellular Longevity (Web)  (Oxidative Med Cell Longev (Web))
Volume： 2018  Page： Null  Publication year： 2018 
JST Material Number： U7012A  ISSN： 1942-0900  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Human Mpv17-like protein (M-LP...

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Thesaurus term： *Proteins ,  *human ,  *gene ,  HepG2 cell ,  Mitochondria ,  DNA repair enzyme ,  *completeness ,  *hepatoma ,  Western blotting ,  instability ,  molecular mechanism ,  *DNA, Mitochondrial ,  *oxoguanine DNA glycosylase 1 ,  *TFAM protein ,  Cas9 protein ,  bioassay
Semi thesaurus term： Cas9 , 【Automatic Indexing@JST】

JST classification (2)： Cell physiology in general  (EF02010S) ,  Function of cell components  (EF03060C)

Reference (43)：

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• M. Albring, J. Griffith, G. Attardi, "Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication," Proceedings of the National Academy of Sciences of the United States of America, vol. 74, no. 4, pp. 1348-1352, 1977.

Terms in the title (11)： ヒト肝細胞 ,  癌細胞 ,  蛋白質 ,  遺伝子 ,  ノックアウト ,  蛋白質レベル ,  TFAM ,  OGG1 ,  mtDNA ,  完全性 ,  障害