Art

J-GLOBAL ID：201902227808006568   Reference number：19A0168571

Synphilin-1 has neuroprotective effects on MPP⁺-induced Parkinson’s disease model cells by inhibiting ROS production and apoptosis

シンフィリン-1はROS産生とアポトーシスを阻害することによりMPP+誘発Parkinson病モデル細胞に対する神経保護効果を有する【JST・京大機械翻訳】

Author (10)： Shishido Takeo (Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Minami-ku Kasumi, Hiroshima, 734-8551, Japan) ,  Nagano Yoshito (Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Minami-ku Kasumi, Hiroshima, 734-8551, Japan) ,  Araki Mutsuko (Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Minami-ku Kasumi, Hiroshima, 734-8551, Japan) ,  Kurashige Takashi (Department of Neurology, NHO Kure Medical Center, 3-1 Aoyama-cho, Kure, Hiroshima, 737-0023, Japan) ,  Obayashi Hitomi (Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Minami-ku Kasumi, Hiroshima, 734-8551, Japan) ,  Nakamura Takeshi (Department of Internal Medicine, Oyamada Memorial Spa Hospital, 5538-1 Yamada-cho, Yokkaichi, Mie, 512-1111, Japan) ,  Takahashi Tetsuya (Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Minami-ku Kasumi, Hiroshima, 734-8551, Japan) ,  Matsumoto Masayasu (Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Minami-ku Kasumi, Hiroshima, 734-8551, Japan) ,  Matsumoto Masayasu (Sakai City Medical Center, Sakai City Hospital Organization, 1-1-1 Ebaraji-cho Nishi-ku, Sakai, Osaka, 593-8304, Japan) ,  Maruyama Hirofumi (Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Minami-ku Kasumi, Hiroshima, 734-8551, Japan)
Material： Neuroscience Letters  (Neurosci Lett)
Volume： 690  Page： 145-150  Publication year： 2019 
JST Material Number： W0118A  ISSN： 0304-3940  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Synphilin-1, a cytoplasmic pro...

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Thesaurus term： *Apoptosis ,  Western blotting ,  *Parkinson's disease ,  Mitochondria ,  human ,  in vitro experiment ,  pathological state ,  interaction ,  neuron ,  neurotoxicity ,  cytochrome c ,  pathogenesis ,  Caspase 3 ,  alpha-Synuclein ,  *synphilin-1 ,  bioassay

Author keywords (5)： Parkinson’s disease ,  synphilin-1 ,  MPP⁺ ,  Apoptosis ,  Dopaminergic neurodegeneration

JST classification (2)： Basic neurology  (GN01020W) ,  Basic research of other drugs acting on central nervous system  (GW03120U)

Terms in the title (10)： シンフィリン-1 ,  ROS ,  アポトーシス ,  阻害 ,  MPP+ ,  誘発 ,  Parkinson病 ,  モデル ,  細胞 ,  神経保護効果