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J-GLOBAL ID：201902227888340958   Reference number：19A1308208

Oxytocin receptor knockout prairie voles generated by CRISPR/Cas9 editing show reduced preference for social novelty and exaggerated repetitive behaviors

CRISPR/Cas9編集により生成されるオキシトシン受容体ノックアウトプレーリーハタネズミは,社会的新規性および誇張反復行動に対する選択性を低下させる【JST・京大機械翻訳】

Author (11)： Horie Kengo (Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza-Aoba, Aoba-ku, Sendai 980-0845, Miyagi, Japan) ,  Inoue Kiyoshi (Silvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, USA) ,  Suzuki Shingo (Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza-Aoba, Aoba-ku, Sendai 980-0845, Miyagi, Japan) ,  Adachi Saki (Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza-Aoba, Aoba-ku, Sendai 980-0845, Miyagi, Japan) ,  Yada Saori (Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza-Aoba, Aoba-ku, Sendai 980-0845, Miyagi, Japan) ,  Hirayama Takashi (Department of Obstetrics and Gynecology, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan) ,  Hidema Shizu (Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza-Aoba, Aoba-ku, Sendai 980-0845, Miyagi, Japan) ,  Young Larry J. (Silvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, USA) ,  Young Larry J. (Center for Social Neural Networks, University of Tsukuba, Tsukuba, Japan) ,  Young Larry J. (Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, USA) ,  Nishimori Katsuhiko (Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, 468-1, Aramaki Aza-Aoba, Aoba-ku, Sendai 980-0845, Miyagi, Japan)
Material： Hormones and Behavior  (Horm Behav)
Volume： 111  Page： 60-69  Publication year： 2019 
JST Material Number： T0237A  ISSN： 0018-506X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Behavioral neuroendocrinology ...

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Thesaurus term： gene ,  phenotype ,  mutation ,  genome ,  high speed ,  *editing ,  autism ,  neuroscience ,  heredity
Semi thesaurus term： *プレーリー ,  オープンフィールド試験 ,  *ハタネズミ ,  動物モデル ,  神経 ,  *Cas9 , 【Automatic Indexing@JST】

Author keywords (8)： CRISPR/Cas9 ,  Oxytocin receptor ,  Prairie voles ,  Autism spectrum disorder ,  Social novelty preference ,  Social behavior ,  Genome editing ,  Non-traditional models

JST classification (3)： Receptors on cell membrane  (EF04030C) ,  Sex hormones  (EB08050O) ,  Autecology  (EE03020H)

Terms in the title (9)： CRISPR ,  Cas9 ,  編集 ,  オキシトシン受容体 ,  社会 ,  新規性 ,  反復 ,  行動 ,  選択性