Art

J-GLOBAL ID：201902228275933039   Reference number：19A1861468

Effects of Zoledronate on Local and Systemic Production of IL-1β, IL-18, and TNF-α in Mice and Augmentation by Lipopolysaccharide

マウスにおけるIL-1β,IL-18およびTNF-αの局所および全身での産生に及ぼすゾレドロン酸の作用とリポ多糖類による作用増強

Author (9)： Funayama Hiromi (Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine) ,  Tashima Itaru (Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine) ,  Okada Satoru (Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University) ,  Ogawa Takuya (Division of Cell Biology, Department of Pharmaceutical Sciences, School of Pharmacy, International University of Health and Welfare) ,  Yagi Hideki (Division of Immunobiology, Department of Pharmaceutical Sciences, School of Pharmacy, International University of Health and Welfare) ,  Tada Hiroyuki (Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University) ,  Wakita Ryo (Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University) ,  Asada Yoshinobu (Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine) ,  Endo Yasuo (Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 6  Page： 929-936(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *metabolic drug ,...
Semi thesaurus term： Interleukin-18 ,...

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Author keywords (12)： bisphosphonate ,  zoledronate ,  lipopolysaccharide ,  interleuikin-1 (IL-1) ,  interleukin-18 (IL-18) ,  tumor necrosis factor-α (TNF-α) ,  bisphosphonate ,  zoledronate ,  lipopolysaccharide ,  interleuikin-1 (IL-1) ,  interleukin-18 (IL-18) ,  tumor necrosis factor-α (TNF-α)

JST classification (2)： Basic research of other drugs acting on metabolism  (GW13060I) ,  Cell physiology in general  (EF02010S)

Substance index (2)： HMDP ,  Zoledronate

Reference (53)：

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• 2) Adami S, Zamberlan N. Adverse effects of bisphosphonates. A comparative review. Drug Saf., 14, 158-170 (1996).
• 3) Ruggiero SL. Bisphosphonate-related osteonecrosis of the jaw (BRONJ): initial discovery and subsequent development. J. Oral Maxillofac. Surg., 67 (Suppl.), 13-18 (2009).
• 4) Woo SB, Hellstein JW, Kalmar JR. Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann. Intern. Med., 144, 753-761 (2006).
• 5) Yamaguchi K, Oizumi T, Funayama H, Kawamura H, Sugawara S, Endo Y. Osteonecrosis of the jawbones in 2 osteoporosis patients treated with nitrogen-containing bisphosphonates: osteonecrosis reduction replacing NBP with non-NBP (etidronate) and rationale. J. Oral Maxillofac. Surg., 68, 889-897 (2010).

Terms in the title (8)： マウス ,  IL-1β ,  IL-18 ,  TNF-α ,  全身 ,  ゾレドロン酸 ,  リポ多糖類 ,  増強