Art

J-GLOBAL ID：201902228959437790   Reference number：19A2686306

FF-10501 induces caspase-8-mediated apoptotic and endoplasmic reticulum stress-mediated necrotic cell death in hematological malignant cells

FF-10501は血液学的悪性細胞においてカスパーゼ-8媒介アポトーシスと小胞体ストレス媒介壊死性細胞死を誘導する

Author (8)： Matsumoto Taichi (Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Jimi Shiro (Central Laboratory of Pathology and Morphology, Department of Medicine, Fukuoka University, Fukuoka, Japan) ,  Migita Keisuke (Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Terada Kazuki (Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Mori Masayoshi (Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Takamatsu Yasushi (Division of Medical Oncology, Hematology, and Infectious Diseases, Department of Medicine, Fukuoka University, Fukuoka, Japan) ,  Suzumiya Junji (Department of Oncology/Hematology, Shimane University Hospital, Shimane, Japan) ,  Hara Shuuji (Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan)
Material： International Journal of Hematology  (Int J Hematol)
Volume： 110  Issue： 5  Page： 606-617  Publication year： Nov. 2019 
JST Material Number： F0888A  ISSN： 0925-5710  CODEN： IJHEEY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： IMP dehydrogenase ,...
Semi thesaurus term： Molecular Mechanisms of Pharmacological Action ,...

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Author keywords (5)： FF-10501 ,  Apoptosis ,  Necrosis ,  Caspase-8 ,  Endoplasmic reticulum stress

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (7)： 血液学 ,  性細胞 ,  カスパーゼ-8 ,  アポトーシス ,  小胞体ストレス ,  壊死性細胞死 ,  誘導