Art

J-GLOBAL ID：201902229273467886   Reference number：19A0865136

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

オレキシン1受容体アンタゴニストYNT-707の必須構造 III 4,5-エポキシ環を欠くYNT-707誘導体におけるオレキシン1受容体に対するきっ抗活性における14-ヒドロキシおよび3-メトキシ基の役割【JST・京大機械翻訳】

Author (15)： Yamamoto Naoshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ohrui Sayaka (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Okada Takahiro (Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan) ,  Saitoh Tsuyoshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Kutsumura Noriki (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Nagumo Yasuyuki (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Irukayama-Tomobe Yoko (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ogawa Yasuhiro (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ishikawa Yukiko (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Watanabe Yurie (School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Hayakawa Daichi (School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Gouda Hiroaki (School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan) ,  Yanagisawa Masashi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Nagase Hiroshi (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Nagase Hiroshi (Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 27  Issue： 8  Page： 1747-1758  Publication year： 2019 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Morphinan derivatives lacking ...

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Thesaurus term： aromaticity ,  *antagonism ,  dewatering ,  side chain ,  *receptor ,  conformational search ,  *Orexins ,  nitrogen heterocyclic compound ,  bridged compound ,  morphinan alkaloid ,  polynuclear aromatic compound
Semi thesaurus term： *アンタゴニスト ,  受容体拮抗薬 , 【Automatic Indexing@JST】

Author keywords (4)： Orexin ,  OX₁R antagonist ,  Morphinan ,  Conformational analysis

JST classification (2)： Structure-activity relationship of drugs  (GV01050B) ,  Synthesis of drugs  (GV01030F)

Substance index (1)： Morphinan

Terms in the title (10)： オレキシン ,  受容体アンタゴニスト ,  YNT-707 ,  環 ,  誘導体 ,  受容体 ,  きっ抗 ,  活性 ,  メトキシ基 ,  役割