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J-GLOBAL ID：201902229302497314   Reference number：19A1491008

Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice

マウスにおける条件付きおよび特異的に標的化された遺伝子アブレーションによる炎症および免疫におけるIRF3の役割の再考【JST・京大機械翻訳】

Author (18)： Yanai Hideyuki (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan) ,  Yanai Hideyuki (Max Planck-The University of Tokyo Center for Integrative Inflammology, 153-8505 Tokyo, Japan) ,  Chiba Shiho (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan) ,  Hangai Sho (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan) ,  Hangai Sho (Max Planck-The University of Tokyo Center for Integrative Inflammology, 153-8505 Tokyo, Japan) ,  Kometani Kohei (Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany) ,  Inoue Asuka (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan) ,  Inoue Asuka (Japan Research and Open Innovation, 163-1488 Tokyo, Japan) ,  Kimura Yoshitaka (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan) ,  Abe Takaya (Animal Resource Development Unit and Genetic Engineering Team, RIKEN Center for Life Science Technologies, 650-0047 Kobe, Japan) ,  Kiyonari Hiroshi (Animal Resource Development Unit and Genetic Engineering Team, RIKEN Center for Life Science Technologies, 650-0047 Kobe, Japan) ,  Nishio Junko (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan) ,  Taguchi-Atarashi Naoko (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan) ,  Mizushima Yu (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan) ,  Negishi Hideo (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan) ,  Grosschedl Rudolf (Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany) ,  Taniguchi Tadatsugu (Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan) ,  Taniguchi Tadatsugu (Max Planck-The University of Tokyo Center for Integrative Inflammology, 153-8505 Tokyo, Japan)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 115  Issue： 20  Page： 5253-5258  Publication year： 2018 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： IFN regulatory factor 3 (IRF3)...

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Thesaurus term： T cell ,  inactivation ,  Septicemia ,  *ablation ,  Serum ,  in vitro experiment ,  *targeting ,  *Mus musculus ,  transcription factor ,  subset ,  natural immunity ,  *Inflammation ,  bacterial infection (disease) ,  immune cell ,  cell type ,  controlling element ,  *Myomorpha

Author keywords (5)： IRF3 ,  infection ,  Bcl2l12 ,  interferon ,  inflammation

JST classification (1)： Immunological reaction in general  (ED03010T)

Terms in the title (8)： マウス ,  標的化 ,  遺伝子 ,  アブレーション ,  炎症 ,  免疫 ,  IRF3 ,  役割