Art

J-GLOBAL ID：201902229736669540   Reference number：19A0487468

Dominant-negative p53 mutant R248Q increases the motile and invasive activities of oral squamous cell carcinoma cells

ドミナントネガティブp53変異体R248Qは口腔扁平上皮癌細胞の運動性活性および浸潤活性を増加させる

Author (10)： NAKAZAWA Seitaro (Department of Gerodontology, Division of Oral Health Science, Graduate School of Dental Medicine) ,  SAKATA Ken-ichiro (Department of Oral Diagnosis and Oral Medicine, Division of Oral Pathobiological Science, Graduate School of Dental Medicine) ,  LIANG Shanshan (The Key Laboratory of Biomarker High Throughput-Screening and Target Translation of Breast and Gastrointestinal Tumor, Oncology department of Affiliated Zhongshan Hospital of Dalian University) ,  YOSHIKAWA Kazuhito (Department of Oral Diagnosis and Oral Medicine, Division of Oral Pathobiological Science, Graduate School of Dental Medicine) ,  IIZASA Hisashi (Department of Microbiology, Shimane University Faculty of Medicine) ,  TADA Mitsuhiro (Department of Neurosurgery, Rumoi Municipal Hospital) ,  HAMADA Jun-ichi (Health Sciences University of Hokkaido, School of Nursing and Social Services) ,  KASHIWAZAKI Haruhiko (Section of Geriatric Dentistry and Perioperative Medicine in Dentistry, Division of Maxillofacial Diagnostic and Surgical Sciences Faculty of Dental Science) ,  KITAGAWA Yoshimasa (Department of Oral Diagnosis and Oral Medicine, Division of Oral Pathobiological Science, Graduate School of Dental Medicine) ,  YAMAZAKI Yutaka (Department of Gerodontology, Division of Oral Health Science, Graduate School of Dental Medicine)
Material： Biomedical Research (Web)
Volume： 40  Issue： 1  Page： 37-49(J-STAGE)  Publication year： 2019 
JST Material Number： U1102A  ISSN： 1880-313X  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *Recurrence of tumor

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JST classification (3)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumors(=neoplasms)of tooth and mouth(=oral cavity)  (GT04000N) ,  Molecular genetics in general  (EC02010J)

Reference (13)：

• 1 Albrecht-Buehler G (1977) The phagokinetic tracks of 3T3 cells. Cell 11, 395-404.
• 2 Frazier MW, He X, Wang J, Gu Z, Cleaveland JL and Zambetti GP (1998) Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain. Mol Cell Biol 18, 3735-3743.
• 3 Hassan, N, Tada M, Hamada J, Kashiwazaki H, Kameyama T, Akhter R, Yamazaki Y, Yano M, Inoue N and Moriuchi T (2008) Presence of dominant negative mutation of TP53 is a risk of early recurrence in oral cancer. Cancer Letter 270, 108-19.
• 4 Kashiwazaki, H., Tonoki H, Tada M, Chiba I, Shindoh M, Totsuka Y, Iggo R and Moriuchi T (1997) High frequency of p53 mutations in human oral epithelial dysplasia and primary squamous cell carcinoma detected by yeast functional assay. Oncogene 15, 2667-2674.
• 5 Lane DP (1992) Cancer. p53, guardian of genome. Nature 358, 15-16.

Terms in the title (7)： ドミナントネガティブ ,  p53 ,  変異体 ,  口腔扁平上皮癌細胞 ,  運動性 ,  活性 ,  浸潤