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J-GLOBAL ID：201902229995504022   Reference number：19A0929447

Early administration of dapagliflozin preserves pancreatic β-cell mass through a legacy effect in a mouse model of type 2 diabetes

ダパグリフロジンの早期投与は2型糖尿病のマウスモデルにおいてレガシー効果を介して膵臓β細胞量を維持する

Author (13)： Kanno Ayumi (Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Asahara Shun-ichiro (Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Kawamura Mao (Division of Metabolism and Disease, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan) ,  Furubayashi Ayuko (Division of Metabolism and Disease, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan) ,  Tsuchiya Shoko (Division of Metabolism and Disease, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan) ,  Suzuki Emi (Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Takai Tomoko (Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Koyanagi-Kimura Maki (Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Matsuda Tomokazu (Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Okada Yuko (Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Ogawa Wataru (Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Kido Yoshiaki (Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Kido Yoshiaki (Division of Metabolism and Disease, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan)
Material： Journal of Diabetes Investigation (Web)  (JDI (Web))
Volume： 10  Issue： 3  Page： 577-590  Publication year： 2019 
JST Material Number： U0507A  ISSN： 2040-1124  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *hypoglycemic drug ,...
Semi thesaurus term： *pancreatic beta-cell ,...

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Author keywords (3)： Pancreatic β-cell ,  Sodium-glucose cotransporter 2 ,  Type 2 diabetes mellitus

JST classification (2)： Basic medicine on endocrine system  (GL01020Q) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Substance index (1)： Dapagliflozin

Terms in the title (5)： ダパグリフロジン ,  早期投与 ,  2型糖尿病 ,  マウスモデル ,  膵臓β細胞