Art

J-GLOBAL ID：201902230093464637   Reference number：19A2455138

ER stress abrogates the immunosuppressive effect of IL-10 on human macrophages through inhibition of STAT3 activation

ERストレスはSTAT3活性化の阻害を介してヒトマクロファージに対するIL-10の免疫抑制効果を抑制する【JST・京大機械翻訳】

Author (14)： Hansen Ivo S. (Amsterdam Rheumatology and Immunology Center, Location Academic Medical Center, Amsterdam, The Netherlands) ,  Hansen Ivo S. (Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands) ,  Schoonejans Josca M. (Amsterdam Rheumatology and Immunology Center, Location Academic Medical Center, Amsterdam, The Netherlands) ,  Schoonejans Josca M. (Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands) ,  Sritharan Lathees (Amsterdam Rheumatology and Immunology Center, Location Academic Medical Center, Amsterdam, The Netherlands) ,  Sritharan Lathees (Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands) ,  van Burgsteden Johan A. (Amsterdam Rheumatology and Immunology Center, Location Academic Medical Center, Amsterdam, The Netherlands) ,  van Burgsteden Johan A. (Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands) ,  Ambarus Carmen A. (Amsterdam Rheumatology and Immunology Center, Location Academic Medical Center, Amsterdam, The Netherlands) ,  Ambarus Carmen A. (Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands) ,  Baeten Dominique L. P. (Amsterdam Rheumatology and Immunology Center, Location Academic Medical Center, Amsterdam, The Netherlands) ,  Baeten Dominique L. P. (Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands) ,  den Dunnen Jeroen (Amsterdam Rheumatology and Immunology Center, Location Academic Medical Center, Amsterdam, The Netherlands) ,  den Dunnen Jeroen (Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands)
Material： Inflammation Research
Volume： 68  Issue： 9  Page： 775-785  Publication year： 2019 
JST Material Number： E0170B  ISSN： 1023-3830  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： To determine whether ER stress...

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Thesaurus term： flow cytometry ,  in vitro experiment ,  *ER stress ,  *immunosuppression ,  targeting ,  inflammation ,  *interleukin 10 ,  *human(primates) ,  transcription factor ,  quantitative polymerase chain reaction ,  pathogenesis ,  cytokine ,  *macrophage ,  alicyclic compound ,  fatty acid ,  lactone ,  olefin compound ,  unsaturated carboxylic acid ,  polyol

Author keywords (5)： Macrophages ,  ER stress ,  Inflammation ,  Cytokines ,  Signal transduction

JST classification (2)： Basic research of anti-inflammatory drugs  (GW15010T) ,  Biophylaxis and immune systems in general  (ED01010F)

Substance index (2)： Tunicamycin ,  Thapsigargin

Terms in the title (7)： ERストレス ,  STAT3 ,  活性化 ,  阻害 ,  IL-10 ,  免疫 ,  抑制効果