Art

J-GLOBAL ID：201902230860348006   Reference number：19A1286706

Novel Approach for the Search for Chemical Scaffolds with Activity at Both Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptor: A Perspective on Scaffolds with Dual Activity for the Treatment of Neurodegenerative Disorders

アセチルコリンエステラーゼとα7ニコチン性アセチルコリン受容体の両方で活性を持つ化学足場を探索するための新規アプローチ:神経変性疾患の治療のための二重活性を持つ足場に関する展望【JST・京大機械翻訳】

Author (12)： Kowal Natalia M. (Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, 107 Reykjavik, Iceland) ,  Kowal Natalia M. (Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia) ,  Kowal Natalia M. (Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia) ,  Indurthi Dinesh C. (Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia) ,  Indurthi Dinesh C. (Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia) ,  Ahring Philip K. (Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia) ,  Ahring Philip K. (Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia) ,  Chebib Mary (Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia) ,  Chebib Mary (Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia) ,  Olafsdottir Elin S. (Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, 107 Reykjavik, Iceland) ,  Balle Thomas (Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia) ,  Balle Thomas (Brain and Mind Centre, The University of Sydney, Camperdown, NSW 2050, Australia)
Material： Molecules (Web)
Volume： 24  Issue： 3  Page： 446  Publication year： 2019 
JST Material Number： U7014A  ISSN： 1420-3049  CODEN： MOLEFW  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Neurodegenerative disorders, i...

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Thesaurus term： natural material ,  interaction ,  Alzheimer Disease ,  database ,  new drug ,  *Acetylcholinesterase ,  nicotinic receptor ,  calculation ,  modeling ,  Lead ,  virtual screening ,  *Neurodegenerative Diseases
Semi thesaurus term： デュアルモード ,  *神経変性 ,  戦術 , 【Automatic Indexing@JST】

Author keywords (10)： virtual screening ,  multi modal ,  dual mode of action ,  nAChR ,  nicotinic acetylcholine receptor ,  AChE ,  acetylcholinesterase ,  docking ,  lead identification ,  neurodegenerative disorders

JST classification (3)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Enzyme in general  (EB09010D) ,  Basic research of other drugs acting on central nervous system  (GW03120U)

Reference (51)：

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Terms in the title (9)： アセチルコリンエステラーゼ ,  α7ニコチン性アセチルコリン受容体 ,  活性 ,  化学 ,  足場 ,  探索 ,  神経変性疾患 ,  治療 ,  展望