Art
J-GLOBAL ID：201902230941797636   Reference number：19A0170007

Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype

ニクロサミド化学型に基づくWnt/βカテニンシグナル伝達の新規トリアゾール阻害剤の同定【JST・京大機械翻訳】
Author (6)：
Mook Robert A.

About Mook Robert A.

(Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States)

About Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States

, 
Wang Jiangbo

About Wang Jiangbo

(Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States)

About Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States

, 
Ren Xiu-Rong

About Ren Xiu-Rong

(Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States)

About Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States

, 
Piao Hailan

About Piao Hailan

(Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States)

About Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States

, 
Lyerly H. Kim

About Lyerly H. Kim

(Department of Surgery, Duke University Medical Center, Durham, NC 27710, United States)

About Department of Surgery, Duke University Medical Center, Durham, NC 27710, United States

, 
Chen Wei

About Chen Wei

(Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States)

About Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States


Material：
Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)

About Bioorganic & Medicinal Chemistry Letters


Volume： 29  Issue： 2  Page： 317-321  Publication year： 2019 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
All summary is available on JDreamIII(charged).
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Dysregulation of the Wnt signa...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
receptor

About receptor

, 
cell proliferation

About cell proliferation

, 
*cellular signal transduction

About cellular signal transduction

, 
in vitro experiment

About in vitro experiment

, 
anthelmintic

About anthelmintic

, 
disease

About disease

, 
*catenin

About catenin


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
標的遺伝子

About 標的遺伝子

, 
Frizzled蛋白質

About Frizzled蛋白質

, 
結腸直腸癌

About 結腸直腸癌

, 
Wntシグナル

About Wntシグナル

, 
*阻害剤

About 阻害剤

, 
*βカテニン

About βカテニン

, 
*Wnt蛋白質

About Wnt蛋白質

, 【Automatic Indexing@JST】
Author keywords (6)：
Niclosamide

About Niclosamide

, 
Wnt signaling inhibitor

About Wnt signaling inhibitor

, 
Small molecule

About Small molecule

, 
Triazole derivatives

About Triazole derivatives

, 
β-Catenin

About β-Catenin

, 
Cancer

About Cancer

JST classification (3)：
JST classification
Category name(code) classified by JST.
Cell physiology in general 
(EF02010S)

About Cell physiology in general

,  Biological function 
(EB03040U)

About Biological function

,  Basic research of antitumor(=antineoplastic)drugs 
(GW16010A)

About Basic research of antitumor(=antineoplastic)drugs

Terms in the title (8)：
Terms in the title
Keywords automatically extracted from the title.
ニクロサミド

About ニクロサミド

, 
化学

About 化学

, 
Wnt

About Wnt

, 
βカテニン

About βカテニン

, 
シグナル伝達

About シグナル伝達

, 
トリアゾール

About トリアゾール

, 
阻害剤

About 阻害剤

, 
同定

About 同定


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