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J-GLOBAL ID：201902231007226162   Reference number：19A1295591

Differential Methylation and Acetylation as the Epigenetic Basis of Resveratrol’s Anticancer Activity

レスベラトロールの抗癌活性のエピジェネティックな基礎としての異なるメチル化とアセチル化【JST・京大機械翻訳】

Author (7)： Farhan Mohd (College of Basic Sciences, King Faisal University, Hofuf 400-Al Ahsa-31982, Saudi Arabia) ,  Ullah Mohammad Fahad (Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, P.O. Box 741, Tabuk 71491, Saudi Arabia) ,  Faisal Mohd (Department of Psychiatry, University Hospital Limerick, Limerick V94 T9PX, Ireland) ,  Farooqi Ammad Ahmad (Institute of Biomedical and Genetic Engineering (IBGE), Islamabad 44000, Pakistan) ,  Sabitaliyevich Uteuliyev Yerzhan (Department of Postgraduate Education and Research, Kazakhstan Medical University KSPH, Almaty 050004, Kazakhstan) ,  Biersack Bernhard (Organic Chemistry Laboratory, Department of Chemistry, University of Bayreuth, Universitaetsstrasse 30, 95447 Bayreuth, Germany) ,  Ahmad Aamir (Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA)
Material： Medicines (Web)
Volume： 6  Issue： 1  Page： 24  Publication year： 2019 
JST Material Number： U7241A  ISSN： 2305-6320  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Numerous studies support the p...

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Thesaurus term： *methylation ,  antitumor drug ,  *antitumor action ,  Ras protein ,  dietary supplement ,  *acetylation ,  carcinogenicity ,  erythrocyte ,  *epigenetics ,  human(primates) ,  robustness ,  olefin compound ,  polyphenol
Semi thesaurus term： ヒストンデアセチラーゼ阻害剤 ,  BRCA1蛋白質 ,  伝達経路 , 【Automatic Indexing@JST】

Author keywords (4)： resveratrol ,  epigenetic ,  methylation ,  acetylation

JST classification (2)： Plant biochemistry  (EH01050J) ,  Essential oils,perfumes  (YG03020H)

Substance index (1)： Resveratrol

Reference (86)：

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• Jang, M.; Cai, L.; Udeani, G.O.; Slowing, K.V.; Thomas, C.F.; Beecher, C.W.; Fong, H.H.; Farnsworth, N.R.; Kinghorn, A.D.; Mehta, R.G.; et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997, 275, 218-220.
• Ahmad, A.; Farhan Asad, S.; Singh, S.; Hadi, S.M. DNA breakage by resveratrol and cu(ii): Reaction mechanism and bacteriophage inactivation. Cancer Lett. 2000, 154, 29-37.
• Ahmad, A.; Syed, F.A.; Singh, S.; Hadi, S.M. Prooxidant activity of resveratrol in the presence of copper ions: Mutagenicity in plasmid DNA. Toxicol. Lett. 2005, 159, 1-12.
• Khan, H.Y.; Zubair, H.; Faisal, M.; Ullah, M.F.; Farhan, M.; Sarkar, F.H.; Ahmad, A.; Hadi, S.M. Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: A mechanism for cancer chemopreventive action. Mol. Nutr. Food Res. 2014, 58, 437-446.

Terms in the title (6)： レスベラトロール ,  抗癌活性 ,  エピジェネティック ,  基礎 ,  メチル化 ,  アセチル化