Art

J-GLOBAL ID：201902231168872615   Reference number：19A0364123

Soluble-type small-molecule CD4 mimics as HIV entry inhibitors

HIV侵入阻害剤としての可溶性型小分子CD4模倣体【JST・京大機械翻訳】

Author (8)： Kobayakawa Takuya (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Konno Kiju (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Ohashi Nami (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Takahashi Kohei (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Masuda Ami (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Yoshimura Kazuhisa (AIDS Research Center, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan) ,  Harada Shigeyoshi (AIDS Research Center, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan) ,  Tamamura Hirokazu (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 29  Issue： 5  Page： 719-723  Publication year： 2019 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Several small molecule CD4 mim...

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Thesaurus term： *solubility(property) ,  phenyl group ,  cytotoxicity ,  hydrophobic ,  *small molecule ,  hydrophilicity ,  interaction ,  *CD4 antigen ,  water solubility ,  HIV1 ,  neutralizing antibody
Semi thesaurus term： ベンゼン環 ,  抗HIV活性 ,  HIVエンベロープ蛋白質gp120 ,  侵入阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Anti-HIV ,  CD4 mimic ,  Pyridinyl group ,  Virus entry inhibitor ,  Water solubility

JST classification (1)： Basic research of antiviral drugs  (GW17040O)

Terms in the title (6)： HIV ,  侵入阻害剤 ,  可溶性 ,  小分子 ,  CD4 ,  模倣