Art

J-GLOBAL ID：201902231448932805   Reference number：19A1341821

Design, synthesis, and biological evaluation of novel 4-oxobenzo[d]1,2,3-triazin-benzylpyridinum derivatives as potent anti-Alzheimer agents

強力な抗Alzheimer薬としての新規4-オキソベンゾ[d]1,2,3-トリアジン-ベンジルピリジニウム誘導体の設計,合成および生物学的評価【JST・京大機械翻訳】

Author (7)： Hosseini Fahimeh (Department of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan, Iran) ,  Ramazani Ali (Department of Chemistry, University of Zanjan, P.O. Box 45195-313, Zanjan, Iran) ,  Mohammadi-Khanaposhtani Maryam (Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran) ,  Barazandeh Tehrani Maliheh (Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran) ,  Nadri Hamid (Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran) ,  Larijani Bagher (Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran) ,  Mahdavi Mohammad (Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 27  Issue： 13  Page： 2914-2922  Publication year： 2019 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Novel 4-oxobenzo[d]1,2,3-triaz...

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Thesaurus term： docking ,  acetylcholinesterase ,  *pyridinium ,  anion ,  oxidative stress ,  interaction ,  rate theory ,  active site ,  *Alzheimer disease ,  aromatic ketone
Semi thesaurus term： β-セクレターゼ ,  神経保護 ,  阻害活性 ,  ブチリルコリンエステラーゼ , 【Automatic Indexing@JST】

Author keywords (5)： Anti-Alzheimer ,  Docking study ,  4-Oxobenzo[d]1 2 3-triazin ,  Benzylpyridinum ,  Neuroprotective activity

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic research of other drugs acting on central nervous system  (GW03120U)

Substance index (2)： Benzil ,  Donepezil

Terms in the title (6)： Alzheimer ,  トリ ,  アジン ,  誘導体 ,  設計 ,  生物学的評価