Art

J-GLOBAL ID：201902231977328057   Reference number：19A0197258

Synthesis and evaluation of 4-(2-fluoro-4-[¹¹C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain

ラット脳における代謝型グルタミン酸受容体2のPETイメージングのための4-(2-フルオロ-4-[~11C]メトキシフェニル)-5-((2-メチルピリジン-4-イル)メトキシ)ピコリンアミドの合成と評価【JST・京大機械翻訳】

Author (10)： Kumata Katsushi (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Hatori Akiko (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Yamasaki Tomoteru (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Zhang Yiding (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Mori Wakana (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Fujinaga Masayuki (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Xie Lin (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Nengaki Nobuki (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan) ,  Nengaki Nobuki (SHI Accelerator Services Co., 1-17-6 Osaki, Shinagawa-ku, Tokyo 141-0032, Japan) ,  Zhang Ming-Rong (Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 27  Issue： 3  Page： 483-491  Publication year： 2019 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Metabotropic glutamate recepto...

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Thesaurus term： precursor (substance) ,  Methylation ,  *Rattus ,  *image processing ,  Eumetopias jubata ,  PET (tomography) ,  *Metabolism ,  Corpus Striatum ,  visualization ,  human ,  in vitro experiment ,  high performance liquid chromatography ,  knockout mouse ,  binding affinity ,  Radioactive Tracers ,  *Myomorpha ,  laboratory animal ,  Mus musculus

Author keywords (5)： Metabotropic glutamate receptor 2 ,  In vitro autoradiography ,  Positron emission tomography ,  Radiotracer ,  Schizophrenia

JST classification (4)： Basic research of radiopharmaceuticals  (GW18010O) ,  Radiodiagnosis  (GC04020K) ,  Labeled compounds  (CB10050N) ,  Nitrogen heterocycles in general  (CF07040G)

Terms in the title (8)： ラット ,  脳 ,  代謝型グルタミン酸受容体2 ,  PET ,  イメージング ,  メチルピリジン ,  ピコリンアミド ,  評価