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J-GLOBAL ID：201902232129410365   Reference number：19A1922012

Epigenetic Changes in the Pathogenesis of Rheumatoid Arthritis

関節リウマチの病因におけるエピジェネティック変化【JST・京大機械翻訳】

Author (17)： Nemtsova Marina V. (Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia) ,  Nemtsova Marina V. (Laboratory of Epigenetics, Research Centre for Medical Genetics, Moscow, Russia) ,  Zaletaev Dmitry V. (Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia) ,  Zaletaev Dmitry V. (Laboratory of Epigenetics, Research Centre for Medical Genetics, Moscow, Russia) ,  Bure Irina V. (Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia) ,  Mikhaylenko Dmitry S. (Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia) ,  Mikhaylenko Dmitry S. (Laboratory of Epigenetics, Research Centre for Medical Genetics, Moscow, Russia) ,  Kuznetsova Ekaterina B. (Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia) ,  Kuznetsova Ekaterina B. (Laboratory of Epigenetics, Research Centre for Medical Genetics, Moscow, Russia) ,  Alekseeva Ekaterina A. (Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia) ,  Alekseeva Ekaterina A. (Laboratory of Epigenetics, Research Centre for Medical Genetics, Moscow, Russia) ,  Beloukhova Marina I. (Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia) ,  Deviatkin Andrei A. (Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia) ,  Lukashev Alexander N. (Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia) ,  Lukashev Alexander N. (Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia) ,  Zamyatnin Andrey A. Jr. (Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia) ,  Zamyatnin Andrey A. Jr. (A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia)
Material： Frontiers in Genetics (Web)
Volume： 10  Page： 570  Publication year： 2019 
JST Material Number： U7071A  ISSN： 1664-8021  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Rheumatoid arthritis (RA) is a...

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Thesaurus term： *epigenetics ,  human(primates) ,  peripheral blood ,  heredity ,  gene expression ,  diagnosis ,  *pathogenesis ,  *rheumatoid arthritis ,  phenotype ,  histone
Semi thesaurus term： ヒストン修飾 ,  非翻訳RNA ,  マイクロRNA ,  DNAメチル化 ,  DNA配列 ,  全身 , 【Automatic Indexing@JST】

Author keywords (6)： rheumatoid arthritis ,  epigenetics ,  DNA methylation ,  miRNA ,  histone modifications ,  circRNA

JST classification (1)： Gene expression  (EC02040Q)

Reference (111)：

• Abdul-Maksoud R., Sediq A., Kattaia A., Elsayed W., Ezzeldin N., Abdel Galil S., et al (2017). Serum miR-210 and miR-155 expression levels as novel biomarkers for rheumatoid arthritis diagnosis. Br. J. Biomed. Sci. 74 209-213. doi: 10.1080/09674845.2017.1343545
• Ai R., Laragione T., Hammaker D., Boyle D. L., Wildberg A., Maeshima K., et al (2018). Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes. Nat. Commun. 9:1921. doi: 10.1038/s41467-018-04310-9
• Ai R., Whitaker J. W., Boyle D. L., Tak P. P., Gerlag D. M., Wang W., et al (2015). DNA methylome signature in synoviocytes from patients with early rheumatoid arthritis compared to synoviocytes from patients with longstanding rheumatoid arthritis. Arthritis Rheumatol. 67 1978-1980. doi: 10.1002/art.39123
• Angiolilli C., Grabiec A. M., Ferguson B. S., Ospelt C., Malvar Fernandez B., van Es I. E., et al (2016). Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression. Ann. Rheum. Dis. 75 430-438. doi: 10.1136/annrheumdis-2014-205635
• Angiolilli C., Kabala P. A., Grabiec A. M., Van Baarsen I. M., Ferguson B. S., García S., et al (2017). Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes. Ann. Rheum. Dis. 76 277-285. doi: 10.1136/annrheumdis-2015-209064

Terms in the title (3)： 関節リウマチ ,  病因 ,  エピジェネティック