Art

J-GLOBAL ID：201902232289246287   Reference number：19A2645366

Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden

高腫瘍変異負荷によるALK陽性肺癌におけるアレクチニブ耐性の迅速獲得【JST・京大機械翻訳】

Author (23)： Makimoto Go (Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) ,  Ohashi Kadoaki (Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) ,  Ohashi Kadoaki (Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan) ,  Tomida Shuta (Okayama University Hospital Biobank, Okayama University Hospital, Okayama, Japan) ,  Nishii Kazuya (Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) ,  Matsubara Takehiro (Okayama University Hospital Biobank, Okayama University Hospital, Okayama, Japan) ,  Kayatani Hiroe (Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) ,  Higo Hisao (Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) ,  Ninomiya Kiichiro (Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) ,  Sato Akiko (Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan) ,  Watanabe Hiromi (Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) ,  Kano Hirohisa (Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) ,  Ninomiya Takashi (Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan) ,  Kubo Toshio (Center for Clinical Oncology, Okayama University Hospital, Okayama, Japan) ,  Rai Kammei (Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan) ,  Ichihara Eiki (Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan) ,  Hotta Katsuyuki (Center of Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan) ,  Tabata Masahiro (Center for Clinical Oncology, Okayama University Hospital, Okayama, Japan) ,  Toyooka Shinichi (Okayama University Hospital Biobank, Okayama University Hospital, Okayama, Japan) ,  Toyooka Shinichi (Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan) ,  Takata Minoru (Laboratory of DNA Damage Signaling, Department of Late Effects Studies, Graduate School of Biostudies, Radiation Biology Center, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, Japan) ,  Maeda Yoshinobu (Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) ,  Kiura Katsuyuki (Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan)
Material： Journal of Thoracic Oncology
Volume： 14  Issue： 11  Page： 2009-2018  Publication year： 2019 
JST Material Number： W3145A  ISSN： 1556-0864  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The highly selective ALK recep...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A2645366&from=J-GLOBAL&jstjournalNo=W3145A") }}

Thesaurus term： gene ,  liver tumor ,  Mutation ,  receptor tyrosine kinase ,  non-small cell lung cancer ,  heterotrans plantation ,  human ,  *tumor ,  man ,  in vitro experiment ,  sensitivity ,  overexpression ,  enzyme inhibitor ,  molecular targeting drug
Semi thesaurus term： 阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： NSCLC ,  Alectinib ,  ALK G1202R ,  MET ,  Amphiregulin

JST classification (1)： Tumors(=neoplasms)of respiratory system  (GI04000G)

Substance index (3)： Erlotinib ,  Crizotinib ,  Alectinib

Terms in the title (6)： 腫瘍 ,  変異 ,  ALK陽性肺癌 ,  アレクチニブ ,  耐性 ,  獲得