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J-GLOBAL ID：201902232401215999   Reference number：19A1280372

miR-542-5p Attenuates Fibroblast Activation by Targeting Integrin α6 in Silica-Induced Pulmonary Fibrosis

miR-542-5pはシリカ誘発肺線維症においてインテグリンα6を標的化することにより線維芽細胞活性化を減弱する【JST・京大機械翻訳】

Author (21)： Yuan Jiali (Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China) ,  Yuan Jiali (The Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University, Nanjing 210029, China) ,  Li Ping (Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China) ,  Li Ping (The Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University, Nanjing 210029, China) ,  Pan Honghong (Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China) ,  Pan Honghong (The Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University, Nanjing 210029, China) ,  Li Yan (Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China) ,  Li Yan (The Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University, Nanjing 210029, China) ,  Xu Qi (Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China) ,  Xu Qi (The Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University, Nanjing 210029, China) ,  Xu Tiantian (Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China) ,  Xu Tiantian (The Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University, Nanjing 210029, China) ,  Ji Xiaoming (Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China) ,  Ji Xiaoming (The Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University, Nanjing 210029, China) ,  Liu Yi (Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China) ,  Liu Yi (The Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University, Nanjing 210029, China) ,  Yao Wenxi (Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China) ,  Yao Wenxi (The Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University, Nanjing 210029, China) ,  Han Lei (Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China) ,  Ni Chunhui (Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 210029, China) ,  Ni Chunhui (The Key Laboratory of Modern Toxicology of Ministry of Education, Nanjing Medical University, Nanjing 210029, China)
Material： International Journal of Molecular Sciences (Web)  (Int J Mol Sci (Web))
Volume： 19  Issue： 12  Page： 3717  Publication year： 2018 
JST Material Number： U7038A  ISSN： 1422-0067  CODEN： IJMCFK  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Silicosis is a very serious oc...

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Thesaurus term： deposition ,  transfection ,  extracellular matrix ,  *silicon dioxide ,  up-regulation ,  *fibroblast ,  phosphorylation ,  *targeting ,  mouse(animal) ,  *integrin ,  silicosis ,  *pulmonary fibrosis ,  *fibrous disease ,  down-regulation ,  pulmonary alveolus

Author keywords (5)： Silicosis ,  miRNA ,  integrin ,  fibroblast ,  proliferation

JST classification (1)： Basic medicine on respiratory system  (GI01020H)

Reference (44)：

• Cullinan, P.; Reid, P. Pneumoconiosis. Prim. Care Respir. J. 2013, 22, 249-252.
• Leung, C.C.; Tak Sun Yu, I.; Chen, W. Silicosis. Lancet 2012, 379, 2008-2018.
• Reid, P.A.; Reid, P.T. Occupational lung disease. J. R. Coll. Phys. Edinb. 2013, 43, 44-48.
• Steenland, K.; Ward, E. Silica: A lung carcinogen. CA Cancer J. Clin. 2014, 64, 63-69.
• Kaminski, N.; Chen, W.; Liu, Y.; Wang, H.; Hnizdo, E.; Sun, Y.; Su, L.; Zhang, X.; Weng, S.; Bochmann, F.; et al. Long-Term Exposure to Silica Dust and Risk of Total and Cause-Specific Mortality in Chinese Workers: A Cohort Study. PLoS Med. 2012, 9, e1001206.

Terms in the title (8)： シリカ ,  誘発 ,  肺線維症 ,  インテグリンα6 ,  標的化 ,  線維芽細胞 ,  活性化 ,  減弱