Art

J-GLOBAL ID：201902232465151732   Reference number：19A1101132

CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells

大細胞外ループ外のCD81受容体領域は肝細胞癌細胞へのC型肝炎ウイルス侵入を決定する【JST・京大機械翻訳】

Author (9)： Banse Pia (Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany) ,  Moeller Rebecca (Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany) ,  Bruening Janina (Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany) ,  Lasswitz Lisa (Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany) ,  Kahl Sina (Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany) ,  Khan Abdul G. (Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA) ,  Marcotrigiano Joseph (Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA) ,  Pietschmann Thomas (Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany) ,  Gerold Gisa (Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, 30625 Hannover, Germany)
Material： Viruses (Web)
Volume： 10  Issue： 4  Page： 207  Publication year： 2018 
JST Material Number： U7293A  ISSN： 1999-4915  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Hepatitis C virus (HCV) enters...

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Thesaurus term： *receptor ,  human(primates) ,  *hepatoma ,  *hepatitis C virus ,  glycoprotein ,  interaction ,  chimera ,  homology(characteristic) ,  sensitivity ,  sterol ,  alicyclic alcohol
Semi thesaurus term： CD9抗原 ,  ドメイン構造 ,  テトラスパニン ,  *侵入 ,  *CD81抗原 , 【Automatic Indexing@JST】

Author keywords (9)： hepatitis C virus ,  HCV ,  tetraspanin ,  CD81 ,  receptor ,  chimeras ,  susceptibility-determining domains ,  transmembrane domain four ,  cholesterol-binding residue

JST classification (1)： Physiology and pathogenicity of virus infection  (EG04042Y)

Substance index (1)： Cholesterol

Reference (88)：

• Mercer, J.; Schelhaas, M.; Helenius, A. Virus entry by endocytosis. Annu. Rev. Biochem. 2010, 79, 803-833.
• Gerold, G.; Bruening, J.; Pietschmann, T. Decoding protein networks during virus entry by quantitative proteomics. Virus Res. 2016, 218, 25-39.
• Dubuisson, J.; Penin, F.; Moradpour, D. Interaction of hepatitis C virus proteins with host cell membranes and lipids. Trends Cell Biol. 2002, 12, 517-523.
• Alvisi, G.; Madan, V.; Bartenschlager, R. Hepatitis C virus and host cell lipids: An intimate connection. RNA Biol. 2011, 8, 258-269.
• Gerold, G.; Bruening, J.; Weigel, B.; Pietschmann, T. Protein Interactions during the Flavivirus and Hepacivirus Life Cycle. Mol. Cell Proteom. 2017, 16, S75-S91.

Terms in the title (7)： ループ ,  CD81 ,  受容体 ,  肝細胞 ,  癌細胞 ,  C型肝炎ウイルス ,  侵入