Art

J-GLOBAL ID：201902232685117907   Reference number：19A0784896

Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction

黒質のドーパミン作動性ニューロンにおけるグレリン受容体のダウンレギュレーションはParkinson病様運動機能障害に寄与する【JST・京大機械翻訳】

Author (18)： Suda Yukari (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan) ,  Kuzumaki Naoko (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan) ,  Kuzumaki Naoko (Department of Physiology, Keio University School of Medicine, Tokyo, Japan) ,  Sone Takefumi (Department of Physiology, Keio University School of Medicine, Tokyo, Japan) ,  Narita Michiko (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan) ,  Tanaka Kenichi (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan) ,  Hamada Yusuke (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan) ,  Iwasawa Chizuru (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan) ,  Shibasaki Masahiro (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan) ,  Maekawa Aya (Laboratory of Molecular Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan) ,  Matsuo Miri (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan) ,  Akamatsu Wado (Department of Physiology, Keio University School of Medicine, Tokyo, Japan) ,  Akamatsu Wado (Center for Genomic and Regenerative Medicine, Juntendo University, School of Medicine, Tokyo, Japan) ,  Hattori Nobutaka (Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan) ,  Okano Hideyuki (Department of Physiology, Keio University School of Medicine, Tokyo, Japan) ,  Okano Hideyuki (Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan) ,  Narita Minoru (Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan) ,  Narita Minoru (Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan)
Material： Molecular Brain (Web)
Volume： 11  Issue： 1  Page： 6  Publication year： 2018 
JST Material Number： U7335A  ISSN： 1756-6606  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Ghrelin exerts a wide range of...

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Thesaurus term： *neuron ,  therapy ,  *Down-Regulation ,  *dysfunction ,  *Substantia Nigra ,  Phenotype ,  human ,  *Parkinson's disease ,  Mutation ,  microinjection ,  *Ghrelin ,  isogene ,  growth hormone secretagogue receptor ,  endogenous ,  Cas9 protein ,  *Mesencephalon ,  *telencephalon ,  *Prosencephalon ,  *basal ganglia
Semi thesaurus term： アンタゴニスト ,  Cas9 , 【Automatic Indexing@JST】

Author keywords (5)： Parkinson’s disease ,  Ghrelin ,  GHSR ,  iPS ,  Dopamine neuron

JST classification (2)： Central nervous system  (EJ12030F) ,  Basic neurology  (GN01020W)

Reference (28)：

• Hum Mol Genet; A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease; N Abbas, CB Lücking, S Ricard, A Dürr, V Bonifati, G De Michele, S Bouley, JR Vaughan, T Gasser, R Marconi; 8; 1999; 567-574; 10.1093/hmg/8.4.567; citation_id=CR1
• Nature; Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism; T Kitada, S Asakawa, N Hattori, H Matsumine, Y Yamamura, S Minoshima, M Yokochi, Y Mizuno, N Shimizu; 392; 1998; 605-608; 10.1038/33416; citation_id=CR2
• Dawson TM. Parkin and defective ubiquitination in Parkinson's disease. J Neural Transm Suppl. 2006:209-13.
• Trends Neurosci; Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease; D Sulzer; 30; 2007; 244-250; 10.1016/j.tins.2007.03.009; citation_id=CR4
• Biochim Biophys Acta; Ubiquitin, proteasome and parkin; K Tanaka, T Suzuki, N Hattori, Y Mizuno; 1695; 2004; 235-247; 10.1016/j.bbamcr.2004.09.026; citation_id=CR5

Terms in the title (6)： 黒質 ,  ドーパミン作動性ニューロン ,  グレリン受容体 ,  ダウンレギュレーション ,  Parkinson病 ,  運動機能障害