Art

J-GLOBAL ID：201902232690506281   Reference number：19A2709610

A quantitative systems pharmacology model of colonic motility with applications in drug development

薬物開発における応用による結腸運動性の定量的システム薬理学モデル【JST・京大機械翻訳】

Author (12)： Das Raibatak (Applied BioMath, Concord, MA, USA) ,  Wille Lucia (Applied BioMath, Concord, MA, USA) ,  Zhang Liming (Takeda Pharmaceutical Inc., Cambridge, MA, USA) ,  Chen Chunlin (Takeda Pharmaceutical Inc., Cambridge, MA, USA) ,  Winchester Wendy (Takeda Pharmaceutical Inc., Cambridge, MA, USA) ,  Selimkhanov Jangir (Takeda Pharmaceutical Inc., Cambridge, MA, USA) ,  Wykosky Jill (Takeda Pharmaceutical Inc., Cambridge, MA, USA) ,  Apgar Joshua F. (Applied BioMath, Concord, MA, USA) ,  Burke John M. (Applied BioMath, Concord, MA, USA) ,  Rogge Mark (Takeda Pharmaceutical Inc., Cambridge, MA, USA) ,  Hua Fei (Applied BioMath, Concord, MA, USA) ,  Vakilynejad Majid (Takeda Pharmaceutical Inc., Cambridge, MA, USA)
Material： Journal of Pharmacokinetics and Pharmacodynamics
Volume： 46  Issue： 5  Page： 485-498  Publication year： 2019 
JST Material Number： D0684A  ISSN： 1567-567X  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： We developed a mathematical mo...

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Thesaurus term： modeling ,  constipation ,  voluntary workers ,  physiology ,  secretion(physiology) ,  *colon ,  *pharmacology ,  therapy ,  parameterization ,  phenotype ,  human(primates) ,  defecation ,  movement disorder ,  mathematical model ,  nitrogen heterocyclic compound ,  phenolic compound ,  polynuclear aromatic compound ,  primary amine
Semi thesaurus term： 健康 , 【Automatic Indexing@JST】

Author keywords (7)： Quantitative systems pharmacology ,  5-HT4 receptor ,  GI motility ,  Colon ,  Bowel dysfunction ,  Constipation ,  Enteric nervous system

JST classification (4)： Clinical application of drugs acting on digestive system  (GW09020B) ,  Basic research of drugs acting on digestive system  (GW09010Q) ,  Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G) ,  Clinical medicine on digestive system in general  (GH01030P)

Substance index (1)： Serotonin

Terms in the title (7)： 薬物 ,  開発 ,  応用 ,  結腸運動 ,  定量 ,  薬理学 ,  モデル