Art

J-GLOBAL ID：201902232859867161   Reference number：19A0646541

CCL17 blockade as a therapy for osteoarthritis pain and disease

変形性関節症疼痛と疾患の治療としてのCCL17遮断【JST・京大機械翻訳】

Author (7)： Lee Ming-Chin (The University of Medicine, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia) ,  Saleh Reem (The University of Medicine, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia) ,  Achuthan Adrian (The University of Medicine, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia) ,  Fleetwood Andrew J. (The University of Medicine, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia) ,  Forster Irmgard (Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany) ,  Hamilton John A. (The University of Medicine, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia) ,  Cook Andrew D. (The University of Medicine, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia)
Material： Arthritis Research & Therapy (Web)
Volume： 20  Issue： 1  Page： 62  Publication year： 2018 
JST Material Number： U7412A  ISSN： 1478-6362  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Granulocyte macrophage-colony ...

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Thesaurus term： *osteoarthrosis ,  pathogenesis ,  fibroblast ,  gene expression ,  model ,  Neutrophils ,  cyclooxygenase ,  *pain ,  osteoblast ,  synovial membrane ,  mRNA ,  knockout mouse ,  macrophage ,  *therapy ,  Jmjd3 ,  molecular genetic phenomenon ,  joint(animal) ,  laboratory animal ,  Mus musculus

Author keywords (5)： Osteoarthritis ,  CCL17 ,  Inflammation ,  Targeting ,  Animal models

JST classification (2)： Basic medicine on musculoskeletal system  (GG01020B) ,  Musculoskeletal diseases  (GG03000T)

Reference (67)：

• Bone Res.; Osteoarthritis: toward a comprehensive understanding of pathological mechanism; D Chen, J Shen, W Zhao, T Wang, L Han, JL Hamilton, HJ Im; 5; 2017; 16044; 10.1038/boneres.2016.44; citation_id=CR1
• Ann Rheum Dis.; Synovial tissue inflammation in early and late osteoarthritis; MJ Benito, DJ Veale, O FitzGerald, WB van den Berg, B Bresnihan; 64; 2005; 1263-1267; 10.1136/ard.2004.025270; citation_id=CR2
• Nat Rev Rheumatol.; Emerging regulators of the inflammatory process in osteoarthritis; R Liu-Bryan, R Terkeltaub; 11; 2015; 35-44; 10.1038/nrrheum.2014.162; citation_id=CR3
• Curr Pharm Des.; Biological therapies in osteoarthritis; CY Wenham, M McDermott, PG Conaghan; 21; 2015; 2206-2215; 10.2174/1381612821666150310144940; citation_id=CR4
• Arthritis Res Ther.; Synovitis in osteoarthritis: current understanding with therapeutic implications; A Mathiessen, PG Conaghan; 19; 2017; 18; 10.1186/s13075-017-1229-9; citation_id=CR5

Terms in the title (6)： 変形性関節症 ,  疼痛 ,  疾患 ,  治療 ,  CCL17 ,  遮断