Art

J-GLOBAL ID：201902233190255266   Reference number：19A2033150

Bardoxolone methyl as a novel potent antiviral agent against hepatitis B and C viruses in human hepatocyte cell culture systems.

ヒト肝細胞培養系におけるB型肝炎およびC型ウイルスに対する新規強力抗ウイルス薬としてのバルドキソロンメチル【JST・京大機械翻訳】

Author (18)： Nio Yasunori (Takeda Pharmaceutical Company Limited, Pharmaceutical Research Division, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa, 251-8555, Japan) ,  Sasai Machiko (Laboratory of Tumor Viruses, The Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan) ,  Sasai Machiko (Grad. Sch. of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyoku, Kyoto, 606-8501, Japan) ,  Akahori Yuichi (Laboratory of Tumor Viruses, The Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan) ,  Akahori Yuichi (Grad. Sch. of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyoku, Kyoto, 606-8501, Japan) ,  Okamura Hitomi (Laboratory of Tumor Viruses, The Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan) ,  Okamura Hitomi (Grad. Sch. of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyoku, Kyoto, 606-8501, Japan) ,  Hasegawa Hikari (Laboratory of Tumor Viruses, The Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan) ,  Hasegawa Hikari (Grad. Sch. of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyoku, Kyoto, 606-8501, Japan) ,  Oshima Mizuki (Department Of, Virology II, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan) ,  Oshima Mizuki (Department of Applied Biological Sciences, Tokyo University of Science, Noda, 278-8510, Japan) ,  Watashi Koichi (Department Of, Virology II, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan) ,  Watashi Koichi (Department of Applied Biological Sciences, Tokyo University of Science, Noda, 278-8510, Japan) ,  Wakita Takaji (Department Of, Virology II, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan) ,  Ryo Akihide (Department of Microbiology, Yokohama City University School of Medicine, 3-9 Fuku-ura, Kanazawa-ku, Yokohama-shi, Kanagawa, 236-0004, Japan) ,  Tanaka Yasuhito (Department of Virology and Liver Unit, Nagoya City University Graduate School of Medicinal Sciences, Nagoya, 467-8601, Japan) ,  Hijikata Makoto (Laboratory of Tumor Viruses, The Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan) ,  Hijikata Makoto (Grad. Sch. of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyoku, Kyoto, 606-8501, Japan)
Material： Antiviral Research  (Antivir Res)
Volume： 169  Page： Null  Publication year： 2019 
JST Material Number： D0654B  ISSN： 0166-3542  CODEN： ARSRDR  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Antiviral drugs against hepati...

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Thesaurus term： hepatitis B virus ,  RNA ,  *antiviral drug ,  *cell culture ,  *hepatitis ,  heme oxygenase ,  erythrocyte ,  genome ,  hepatitis C virus ,  *hepatitis B ,  human(primates) ,  *culture(biology)
Semi thesaurus term： 標的遺伝子 ,  NFE2関連因子2 ,  B型肝炎ウイルス感染 , 【Automatic Indexing@JST】

Author keywords (5)： HBV and HCV co-infection ,  Nrf2 activator ,  Heme oxygenase-1 ,  DAAs ,  nucleos(t)ide analogue drugs

JST classification (1)： Basic research of antiviral drugs  (GW17040O)

Substance index (1)： Bardoxolone methyl

Terms in the title (6)： ヒト肝細胞 ,  培養 ,  B型肝炎 ,  C型ウイルス ,  抗ウイルス薬 ,  バルドキソロンメチル