Art

J-GLOBAL ID：201902233634426767   Reference number：19A1706073

Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression

EP2/EP4プロスタノイド受容体仲介シグナル伝達の阻害はγ-グルタミルシクロトランスフェラーゼ発現を上方制御することにより膵臓癌BXPC-3細胞のIGF-1誘導増殖を抑制する【JST・京大機械翻訳】

Author (5)： Takahashi Tetsuyuki (Department of Anatomy and Cell Biology, Faculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University, Nishi-Tokyo, Tokyo, Japan) ,  Ichikawa Hirona (Department of Anatomy and Cell Biology, Faculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University, Nishi-Tokyo, Tokyo, Japan) ,  Morimoto Yuuki (Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan) ,  Tsuneyama Koichi (Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan) ,  Hijikata Takao (Department of Anatomy and Cell Biology, Faculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University, Nishi-Tokyo, Tokyo, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 516  Issue： 2  Page： 388-396  Publication year： 2019 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Inhibition of prostaglandin E<...

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Thesaurus term： ERK ,  Cell Proliferation ,  catalyst ,  phosphorylation ,  *IGF1 ,  *pancreatic tumor ,  *Up-Regulation ,  overexpression ,  Gene Knockdown Technique ,  *gamma-Glutamylcyclotransferase ,  *EP4 ,  *EP2 ,  *Signal Transduction ,  *factor ,  *bioactive factor ,  *growth factor ,  *cytokine
Semi thesaurus term： *cellular signal transduction ,  抑制効果 ,  阻害剤 , 【Automatic Indexing@JST】

JST classification (2)： Function of cell components  (EF03060C) ,  Receptors on cell membrane  (EF04030C)

Terms in the title (13)： EP2 ,  EP4 ,  プロスタノイド受容体 ,  仲介 ,  シグナル伝達 ,  阻害 ,  γ-グルタミルシクロトランスフェラーゼ ,  発現 ,  上方制御 ,  膵臓癌 ,  BxPC-3細胞 ,  誘導 ,  増殖