Art

J-GLOBAL ID：201902233786986769   Reference number：19A2482028

trans-2-Pentenal, an Active Compound in Cigarette Smoke, Identified via Its Ability to Form Adducts with Glutathione

trans-2-ペンテナール,グルタチオンとの付加物形成能により同定されたたばこ煙中の活性化合物

Author (8)： Hatai Mayuko (Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Horiyama Shizuyo (Mukogawa Women’s University, Institute for Bioscience) ,  Yoshikawa Noriko (Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Yoshikawa Noriko (Mukogawa Women’s University, Institute for Bioscience) ,  Kinoshita Eriko (Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Kagota Satomi (Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Shinozuka Kazumasa (Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Nakamura Kazuki (Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 67  Issue： 9  Page： 1000-1005(J-STAGE)  Publication year： 2019 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *antitumor action ,...
Semi thesaurus term： tobacco smoke

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Author keywords (8)： αβ-unsaturated carbonyl compound ,  cigarette smoke ,  glutathione ,  trans-2-pentenal ,  αβ-unsaturated carbonyl compound ,  cigarette smoke ,  glutathione ,  trans-2-pentenal

JST classification (3)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Tobacco(=cigarette)  (FJ07000D) ,  Aliphatic aldehydes  (CF03180F)

Substance index (2)： (E)-2-Pentenal ,  Glutathione

Reference (14)：

• 1) Smith C. J., Fischer T. H., Atherosclerosis, 158, 257-267 (2001).
• 2) Ezzati M., Lopez A. D., Lancet, 362, 847-852 (2003).
• 3) Hoffmann D., Hoffmann I., El-Bayoumy K., Chem. Res. Toxicol., 14, 767-790 (2001).
• 4) IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, IARC Monogr. Eval. Carcinog. Risks Hum., 83, 1-1438 (2004).
• 5) Green C. R., Rodgman A., Recent Adv. Tobacco Sci, 22, 131-304 (1996).

Terms in the title (6)： 2-ペンテナール ,  グルタチオン ,  付加物 ,  同定 ,  たばこ煙 ,  活性化合物