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J-GLOBAL ID：201902233891805684   Reference number：19A2328272

Construction of an Expression Vector Containing Mouse-Rat Chimeric Genes Encoding a Therapeutic Antibody against CD81

CD81に対する治療抗体をコードするマウス-ラットキメラ遺伝子を含む発現ベクターの構築

Author (5)： Yamasaki Tsutomu (Molecular Biology and Clinical Diagnosis, Shujitsu University School of Pharmacy) ,  Arai Yuji (Department of Sports and Para-Sports Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine) ,  Nakagawa Shuji (Department of Sports and Para-Sports Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine) ,  Kubo Toshikazu (Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine) ,  Nakanishi Tohru (Molecular Biology and Clinical Diagnosis, Shujitsu University Graduate School of Pharmacy)
Material： Journal of Hard Tissue Biology  (J Hard Tissue Biol)
Volume： 28  Issue： 3  Page： 239-244(J-STAGE)  Publication year： 2019 
JST Material Number： L2839A  ISSN： 1341-7649  CODEN： JHTBFF  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： hybridoma ,...
Semi thesaurus term： *CD81 ,...

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Author keywords (5)： Rheumatoid arthritis ,  CD81 ,  Monoclonal antibody ,  Chimeric gene ,  Enzyme-linked immunosorbent assay (ELISA)

JST classification (1)： Proteins and peptides in general  (EB03010N)

Reference (19)：

• 1. Levy S, Todd SC and Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol 16: 89-109, 1998
• 2. Horikawa K and Takatsu K. Interleukin-5 regulates genes involved in B-cell terminal maturation. Immunology 118: 497-508, 2006
• 3. Mori H and Nakanishi T. Signal transduction of inflammatory synoviocytes in rheumatoid arthritis. Yakugaku Zasshi 128: 263-268, 2008
• 4. Nakanishi T, Arai Y, Mori H, Nakajima T and Kubo T. Application of tetraspanin CD81 RNAi for diagnosis and therapy of rheumatoid arthritis (RA). Arthr Res Therap 14: 52, 2011
• 5. Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, Aratani S, Fujita H, Zhang L, Ikeda R, Fujii R, Miura N, Komiya S, Nishioka K, Maruyama I, Fukamizu A and Nakajima T. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev 17: 2436-2449, 2003

Terms in the title (7)： CD81 ,  治療抗体 ,  マウス ,  ラット ,  キメラ遺伝子 ,  発現ベクター ,  構築