Art

J-GLOBAL ID：201902234255267085   Reference number：19A1908518

Exploring the Structure-Activity Relationship and Mechanism of a Chromene Scaffold (CXL Series) for Its Selective Antiproliferative Activity toward Multidrug-Resistant Cancer Cells

多剤耐性癌細胞に対する選択的抗増殖活性のためのクロメン足場(CXLシリーズ)の構造活性相関と機構の探索【JST・京大機械翻訳】

Author (14)： Bian Tengfei (Department of Medicinal Chemistry, College of Pharmacy, University of Florida) ,  Chandagirikoppal Vijendra Kavitha (Department of Medicinal Chemistry, College of Pharmacy, University of Florida) ,  Chandagirikoppal Vijendra Kavitha (Department of Chemistry, Government College for Women Mandya, University of Mysore, Karnataka, India) ,  Wang Yi (Department of Medicinal Chemistry, College of Pharmacy, University of Florida) ,  Meacham Amy (Health Cancer Center, University of Florida) ,  Meacham Amy (Division of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida) ,  Hati Santanu (Department of Medicinal Chemistry, College of Pharmacy, University of Florida) ,  Cogle Christopher R. (Health Cancer Center, University of Florida) ,  Cogle Christopher R. (Division of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida) ,  Sun Haifeng (Department of Medicinal Chemistry, College of Pharmacy, University of Florida) ,  Sun Haifeng (Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minnesota, United States) ,  Xing Chengguo (Department of Medicinal Chemistry, College of Pharmacy, University of Florida) ,  Xing Chengguo (Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minnesota, United States) ,  Xing Chengguo (Health Cancer Center, University of Florida)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 61  Issue： 15  Page： 6892-6903  Publication year： 2018 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Multidrug resistance (MDR) is ...

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Thesaurus term： homeostasis ,  *tumor cell ,  probe ,  acute myeloid leukemia ,  *multiple drug resistance ,  safety ,  characterization ,  in vitro experiment ,  lead compound ,  *structure-activity relationship
Semi thesaurus term： 正常細胞 ,  決定因子 ,  増殖能 ,  悪性腫瘍 ,  *抗増殖活性 , 【Automatic Indexing@JST】

JST classification (3)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Synthesis of drugs  (GV01030F) ,  Structure-activity relationship of drugs  (GV01050B)

Terms in the title (7)： 多剤耐性 ,  癌細胞 ,  抗増殖活性 ,  クロメン ,  足場 ,  構造活性相関 ,  探索