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J-GLOBAL ID：201902234340405684   Reference number：19A2622952

Rivaroxaban Promotes Reduction of Embolus Size within Cerebrocortical Microvessels in a Mouse Model of Embolic Stroke

リバロキサバンは塞栓性脳卒中のマウスモデルにおける大脳皮質微小血管内の塞栓サイズの減少を促進する

Author (7)： Katsumata Masahiro (Department of Neurology, Keio University School of Medicine, Tokyo, Japan) ,  Oki Koichi (Department of Neurology, Keio University School of Medicine, Tokyo, Japan) ,  Tsukada Naoki (Department of Neurology, Keio University School of Medicine, Tokyo, Japan) ,  Abe Takato (Department of Neurology, Graduate School of Medicine, Osaka City University, Osaka, Japan) ,  Itoh Yoshiaki (Department of Neurology, Graduate School of Medicine, Osaka City University, Osaka, Japan) ,  Takahashi Shinichi (Department of Neurology, Keio University School of Medicine, Tokyo, Japan) ,  Suzuki Norihiro (Department of Neurology, Keio University School of Medicine, Tokyo, Japan)
Material： Keio Journal of Medicine  (Keio J Med)
Volume： 68  Issue： 3  Page： 45-53(J-STAGE)  Publication year： 2019 
JST Material Number： F0769A  ISSN： 0022-9717  CODEN： KJMEA9  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cerebral embolism ,...
Semi thesaurus term： *Embolic stroke ,...

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Author keywords (6)： rivaroxaban ,  embolic stroke ,  intracranial embolism ,  microvessels ,  prothrombolytic effect ,  direct oral anticoagulants (DOACs)

JST classification (2)： Basic research of drugs acting on blood and body fluid  (GW14010M) ,  Basic medicine on cardiovascular system  (GJ01020K)

Substance index (1)： Rivaroxaban

Reference (22)：

• 1. Ntaios G, Papavasileiou V, Diener HC, Makaritsis K, Michel P: Nonvitamin-K-antagonist oral anticoagulants in patients with atrial fibrillation and previous stroke or transient ischemic attack: a systematic review and meta-analysis of randomized controlled trials. Stroke 2012; 43: 3298-3304. PMID:23150654, DOI:10.1161/STROKEAHA.112.673558
• 2. EAFT (European Atrial Fibrillation Trial) Study Group: Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. Lancet 1993; 342: 1255-1262. PMID:7901582
• 3. Takasugi J, Yamagami H, Okata T, Toyoda K, Nagatsuka K: Dissolution of the left atrial appendage thrombus with rivaroxaban therapy. Cerebrovasc Dis 2013; 36: 322-323. PMID:24192983, DOI:10.1159/000354315
• 4. Kawakami T, Kobayakawa H, Ohno H, Tanaka N, Ishihara H: Resolution of left atrial appendage thrombus with apixaban. Thromb J 2013; 11: 26. PMID:24359320, DOI:10.1186/1477-9560-11-26
• 5. Komori M, Yasaka M, Kokuba K, Matsuoka H, Fujimoto S, Yoshida M, Kameda K, Shono T, Nagata S, Ago T, Kitazono T, Okada Y: Intracranial hemorrhage during dabigatran treatment. Circ J 2014; 78: 1335-1341. PMID:24662438, DOI:10.1253/circj.CJ-13-1534

Terms in the title (8)： リバロキサバン ,  塞栓性脳卒中 ,  マウスモデル ,  大脳皮質 ,  微小血管 ,  塞栓 ,  サイズ ,  促進