Art

J-GLOBAL ID：201902234434719195   Reference number：19A1303875

Cynaropicrin from Cynara scolymus L. suppresses Porphyromonas gingivalis LPS-induced production of inflammatory cytokines in human gingival fibroblasts and RANKL-induced osteoclast differentiation in RAW264.7 cells

Cynara scolymus L.由来のシナロピクリンによるヒト歯肉線維芽細胞におけるPorphyromonas gingivalis LPS誘導炎症性サイトカイン産生,およびRaw264.7細胞におけるRANKL誘導破骨細胞分化の抑制

Author (14)： Hayata Mayumi (Department of Dysphagia Rehabilitation, Nihon University School of Dentistry, Tokyo, Japan) ,  Hayata Mayumi (Department of Microbiology, Nihon University School of Dentistry, Tokyo, Japan) ,  Watanabe Norihisa (Department of Microbiology, Nihon University School of Dentistry, Tokyo, Japan) ,  Watanabe Norihisa (Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan) ,  Kamio Noriaki (Department of Microbiology, Nihon University School of Dentistry, Tokyo, Japan) ,  Tamura Muneaki (Department of Microbiology, Nihon University School of Dentistry, Tokyo, Japan) ,  Nodomi Keiko (Department of Microbiology, Nihon University School of Dentistry, Tokyo, Japan) ,  Tanaka Kiyotaka (Department of Research and Development, Ichimaru Pharcos Co. Ltd, Gifu, Japan) ,  Iddamalgoda Arunasiri (Department of Research and Development, Ichimaru Pharcos Co. Ltd, Gifu, Japan) ,  Tsuda Hiromasa (Department of Biochemistry, Nihon University School of Dentistry, Tokyo, Japan) ,  Ogata Yorimasa (Department of Periodontology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan) ,  Sato Shuichi (Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan) ,  Ueda Kouichiro (Department of Dysphagia Rehabilitation, Nihon University School of Dentistry, Tokyo, Japan) ,  Imai Kenichi (Department of Microbiology, Nihon University School of Dentistry, Tokyo, Japan)
Material： Journal of Natural Medicines  (J Nat Med)
Volume： 73  Issue： 1  Page： 114-123  Publication year： 2019 
JST Material Number： L5856A  ISSN： 1340-3443  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： periodontal disease ,...
Semi thesaurus term： Porphyromonas ,...

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Author keywords (5)： Cynaropicrin ,  Periodontal diseases ,  Inflammatory cytokine ,  Human gingival fibroblasts ,  Osteoclast differentiation

JST classification (2)： Monoterpenes,sesquiterpenes  (CF10022A) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (1)： Cynaropicrin

Terms in the title (13)： Cynara ,  Scolymus ,  シナロピクリン ,  ヒト ,  歯肉線維芽細胞 ,  Porphyromonas ,  LPS ,  誘導 ,  炎症 ,  サイトカイン産生 ,  細胞 ,  RANKL ,  破骨細胞分化