Art

J-GLOBAL ID：201902234435192501   Reference number：19A0768256

Novel Ridaifen-B Structure Analog Induces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain

新規のリダイフェンB構造類似体はピロリジン側鎖に依存してアポトーシスとオートファジーを誘導する

Author (7)： Iwasawa Takumi (Graduate School of Advanced Science and Technology, Tokyo Denki University) ,  Shinomiya Takahisa (Graduate School of Advanced Science and Technology, Tokyo Denki University) ,  Ota Nozomi (Faculty of Science, Tokyo University of Science) ,  Shibata Natsumi (Faculty of Science, Tokyo University of Science) ,  Nakata Kenya (Graduate School of Science and Engineering, Shimane University) ,  Shiina Isamu (Faculty of Science, Tokyo University of Science) ,  Nagahara Yukitoshi (Graduate School of Advanced Science and Technology, Tokyo Denki University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 3  Page： 401-410(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *apoptosis ,...
Semi thesaurus term： Atg5 ,...

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Author keywords (10)： ridaifen ,  tamoxifen ,  apoptosis ,  autophagy ,  mitophagy ,  ridaifen ,  tamoxifen ,  apoptosis ,  autophagy ,  mitophagy

JST classification (2)： Basic oncology in general  (GE02010R) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： Pyrrolidine ,  Ridaifen B

Reference (36)：

• 1) Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 26, 239-257 (1972).
• 2) Majno G, Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol., 146, 3-15 (1995).
• 3) Yang Z, Klionsky DJ. Mammalian autophagy core molecular machinery and signaling regulation. Curr. Opin. Cell Biol., 22, 124-131 (2010).
• 4) Han W, Pan H, Chen Y, Sun J, Wang Y, Li J, Ge W, Feng L, Lin X, Wang X, Wang X, Jin H. EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS ONE, 6, e18691 (2011).
• 5) Mandlekar S, Kong AN. Mechanisms of tamoxifen-induced apoptosis. Apoptosis, 6, 469-477 (2001).

Terms in the title (7)： リダイフェンB ,  類似体 ,  ピロリジン ,  側鎖 ,  アポトーシス ,  オートファジー ,  誘導