Art

J-GLOBAL ID：201902234566240201   Reference number：19A0714956

PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue

PIK3CA変異は食道癌における好ましい予後因子である: 外科的に切除されたホルマリン固定,パラフィン包埋組織を用いた次世代シークエンシングによる分子プロファイル【JST・京大機械翻訳】

Author (9)： Yokota Tomoya (Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan) ,  Serizawa Masakuni (Drug Discovery and Development Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan) ,  Hosokawa Ayumu (Department of Gastroenterology and Hematology, faculty of Medicine, University of Toyama, Toyama, Japan) ,  Kusafuka Kimihide (Pathology Division, Shizuoka Cancer Center, Shizuoka, Japan) ,  Mori Keita (Clinical Trial Coordination Office, Shizuoka Cancer Center, Shizuoka, Japan) ,  Sugiyama Toshiro (Department of Gastroenterology and Hematology, faculty of Medicine, University of Toyama, Toyama, Japan) ,  Tsubosa Yasuhiro (Division of Esophageal Surgery, Shizuoka Cancer Center, Shizuoka, Japan) ,  Koh Yasuhiro (Drug Discovery and Development Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan) ,  Koh Yasuhiro (Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan)
Material： BMC Cancer (Web)
Volume： 18  Issue： 1  Page： 826  Publication year： 2018 
JST Material Number： U7305A  ISSN： 1471-2407  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Practical and reliable genotyp...

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Thesaurus term： immunohistochemistry ,  biomarker ,  DNA ,  *surgery ,  human(primates) ,  *prognosis ,  *esophageal tumor ,  mutation ,  heredity ,  massively parallel processing ,  gene ,  smoking(tobacco) ,  stratification
Semi thesaurus term： アンプリコン ,  転帰 ,  *ホルマリン固定 , 【Automatic Indexing@JST】

Author keywords (5)： Esophageal cancer ,  Formalin-fixed paraffin-embedded tissue ,  Next-generation sequencing ,  PIK3CA mutation ,  Prognostic factors

JST classification (4)： Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Urogenital tumors(=neoplasms)  (GM04000S) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Molecular genetics in general  (EC02010J)

Reference (43)：

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• Ann Surg Oncol; A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907); N Ando, H Kato, H Igaki; 19; 2012; 68-74; 10.1245/s10434-011-2049-9; citation_id=CR3
• N Engl J Med; Preoperative chemoradiotherapy for esophageal or junctional cancer; P van Hagen, MC Hulshof, JJ van Lanschot; 366; 2012; 2074-2084; 10.1056/NEJMoa1112088; citation_id=CR4
• Ann Surg; Long-term outcome of 2920 patients with cancers of the esophagus and esophagogastric junction: evaluation of the new union Internationale Contre le Cancer/American joint Cancer committee staging system; R Gertler, HJ Stein, R Langer; 253; 2011; 689-698; 10.1097/SLA.0b013e31821111b5; citation_id=CR5

Terms in the title (10)： PIK3CA ,  変異 ,  食道癌 ,  予後因子 ,  外科 ,  ホルマリン固定 ,  パラフィン包埋組織 ,  次世代シークエンシング ,  分子 ,  プロファイル