Art

J-GLOBAL ID：201902234838698855   Reference number：19A1706108

A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves Cognition

新規アポリポ蛋白質Eアンタゴニストはアポリポ蛋白質EとN末端アミロイド前駆体蛋白質との相互作用を機能的に遮断し,β-アミロイド関連病理を減少させ,認知を改善する【JST・京大機械翻訳】

Author (12)： Sawmiller Darrell (Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida) ,  Habib Ahsan (Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida) ,  Hou Huayan (Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida) ,  Mori Takashi (Departments of Biomedical Sciences and Pathology, Saitama Medical Center and Saitama Medical University, Kawagoe, Saitama, Japan) ,  Fan Anran (Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida) ,  Tian Jun (Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida) ,  Zeng Jin (Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida) ,  Giunta Brian (Neuroimmunology Laboratory, Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida) ,  Sanberg Paul R. (Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, Florida) ,  Mattson Mark P. (Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland) ,  Mattson Mark P. (Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland) ,  Tan Jun (Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, Florida)
Material： Biological Psychiatry  (Journal of Psychiatry Research)
Volume： 86  Issue： 3  Page： 208-220  Publication year： 2019 
JST Material Number： T0089A  ISSN： 0006-3223  CODEN： BIPCBF  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The ε4 isoform of apolipoprote...

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Thesaurus term： *interaction ,  *Amyloid ,  binding site ,  *amyloid beta-protein ,  Alzheimer Disease ,  synapse ,  phosphorylation ,  *pathological state ,  peptide ,  transgenic mouse ,  isoform ,  Apolipoprotein E4 ,  *amino terminal ,  *Proteins ,  *glycoprotein ,  *animal protein ,  sterol ,  alicyclic alcohol
Semi thesaurus term： *アンタゴニスト , 【Automatic Indexing@JST】

Author keywords (7)： Acetylated and phosphorylated tau ,  Alzheimer’s disease ,  Alzheimer’s mouse model ,  Amyloid precursor protein ,  Amyloidogenesis ,  Apolipoprotein E ,  Low-density lipoprotein receptor binding domain

JST classification (3)： Biological function  (EB03040U) ,  Nervous system diseases  (GN03000O) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Cholesterol

Terms in the title (11)： アポリポ蛋白質E ,  アンタゴニスト ,  N末端 ,  アミロイド ,  前駆体 ,  蛋白質 ,  相互作用 ,  遮断 ,  β-アミロイド ,  病理 ,  認知