Art

J-GLOBAL ID：201902235017748013   Reference number：19A1954918

Cyclic Stretch Force Induces Periodontal Ligament Cells to Secrete Exosomes That Suppress IL-1β Production Through the Inhibition of the NF-κB Signaling Pathway in Macrophages

周期的伸長力はマクロファージにおけるNF-κBシグナル伝達経路の阻害を介してIL-1β産生を抑制するエキソソームを分泌するために歯周靭帯細胞を誘導する【JST・京大機械翻訳】

Author (9)： Wang Zhuyu (Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Maruyama Kentarou (Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Sakisaka Yukihiko (Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Suzuki Shigeki (Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Tada Hiroyuki (Department of Oral Immunology, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Suto Mizuki (Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Saito Masahiro (Department of Restorative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Yamada Satoru (Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Nemoto Eiji (Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan)
Material： Frontiers in Immunology (Web)
Volume： 10  Page： 1310  Publication year： 2019 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： In the oral mechanical environ...

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Thesaurus term： *NF-kappaB ,  transmission electron microscope ,  monocyte ,  siRNA ,  inflammation ,  human(primates) ,  pretreatment ,  *macrophage ,  homeostasis ,  *interleukin 1 ,  *secretion(physiology)
Semi thesaurus term： 阻害剤 ,  *インターロイキン1β ,  炎症反応 ,  *エキソソーム , 【Automatic Indexing@JST】

Author keywords (6)： exosomes ,  cyclic stretch ,  NF-κB signaling ,  inflammasome ,  periodontal ligament cells ,  macrophages

JST classification (2)： Cell physiology in general  (EF02010S) ,  Infectious immunity  (ED03030P)

Reference (62)：

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• Pavasant P, Yongchaitrakul T. Role of mechanical stress on the function of periodontal ligament cells. Periodontol 2000. (2011) 56:154-65. doi: 10.1111/j.1600-0757.2010.00374.x
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• Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. (2002) 10:417-26. doi: 10.1038/nri3070

Terms in the title (10)： マクロファージ ,  NF-κB ,  シグナル伝達経路 ,  阻害 ,  IL-1β ,  エキソソーム ,  分泌 ,  歯周靭帯 ,  細胞 ,  誘導