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J-GLOBAL ID：201902235036535654   Reference number：19A1922707

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy

PDGF経路の活性化がLMNA変異を拡張型心筋症に結び付ける

Author (63)： LEE Jaecheol (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  TERMGLINCHAN Vittavat (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  ITZHAKI Ilanit (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  LAM Chi Keung (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  GARG Priyanka (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  LAU Edward (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  SEEGER Timon (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  WU Haodi (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  ZHANG Joe Z. (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  GIL Isaac Perea (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  AMEEN Mohamed (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  SALLAM Karim (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  RHEE June-Wha (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  CHURKO Jared M. (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  CHAUDHARY Rinkal (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  CHOUR Tony (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  SNYDER Michael P. (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  KARAKIKES Ioannis (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  WU Joseph C. (Stanford Cardiovascular Inst., Stanford Univ., Stanford, CA, USA) ,  LEE Jaecheol (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  TERMGLINCHAN Vittavat (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  ITZHAKI Ilanit (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  LAM Chi Keung (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  GARG Priyanka (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  LAU Edward (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  SEEGER Timon (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  WU Haodi (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  ZHANG Joe Z. (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  AMEEN Mohamed (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  SALLAM Karim (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  RHEE June-Wha (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  CHURKO Jared M. (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  CHAUDHARY Rinkal (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  CHOUR Tony (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  WANG Paul J. (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  WU Joseph C. (Dep. of Medicine, Div. of Cardiovascular Medicine, Stanford Univ., Stanford, CA, USA) ,  LEE Jaecheol (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  TERMGLINCHAN Vittavat (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  ITZHAKI Ilanit (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  LAM Chi Keung (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  GARG Priyanka (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  LAU Edward (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  SEEGER Timon (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  WU Haodi (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  ZHANG Joe Z. (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  AMEEN Mohamed (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  SALLAM Karim (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  RHEE June-Wha (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  CHURKO Jared M. (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  CHAUDHARY Rinkal (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  CHOUR Tony (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  WU Joseph C. (Inst. for Stem Cell Biology and Regenerative Medicine, Stanford Univ., Stanford, CA, USA) ,  LEE Jaecheol (School of Pharmacy, Sungkyunkwan Univ., Suwon, KOR) ,  DIECKE Sebastian (Berlin Inst. of Health, Berlin, DEU) ,  DIECKE Sebastian (Max Delbrueck Center, Berlin, DEU) ,  DIECKE Sebastian (DZHK (German Centre for Cardiovascular Res.), partner site Berlin, Berlin, DEU) ,  GREENHAW Matthew (Dep. of Cardiothoracic Surgery, Stanford Univ. School of Medicine, Stanford, CA, USA) ,  GIL Isaac Perea (Dep. of Cardiothoracic Surgery, Stanford Univ. School of Medicine, Stanford, CA, USA) ,  KARAKIKES Ioannis (Dep. of Cardiothoracic Surgery, Stanford Univ. School of Medicine, Stanford, CA, USA) ,  CHEN Xingqi (Center for Personal Dynamic Regulomes, Stanford Univ., Stanford, CA, USA) ,  CHANG Howard Y. (Center for Personal Dynamic Regulomes, Stanford Univ., Stanford, CA, USA) ,  SNYDER Michael P. (Dep. of Genetics, Stanford Univ. School of Medicine, Stanford, CA, USA) ,  CHANG Howard Y. (Howard Hughes Medical Inst., Stanford Univ., Stanford, CA, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 572  Issue： 7769  Page： 335-340  Publication year： Aug. 15, 2019 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： in vitro experiment ,  Phenotype ,  gene ,  pathogenesis ,  Heredity ,  human ,  *PDGF ,  Calcium ,  Cardiac Myocyte ,  arrhythmia ,  isogene ,  single cell ,  Lamin Type A ,  *Genetic Variation ,  signal transduction pathway
Semi thesaurus term： *variation(biology) ,  伝達経路 ,  収縮不全 , 【Automatic Indexing@JST】

JST classification (4)： Heart  (EJ04020D) ,  Biological function  (EB03040U) ,  Genetic variation  (EC01030Y) ,  Development(=generation)and differentiation  (EJ16020W)

Terms in the title (5)： PDGF ,  経路 ,  活性化 ,  変異 ,  拡張型心筋症