Art

J-GLOBAL ID：201902235155666878   Reference number：19A1921789

Airway M Cells Arise in the Lower Airway Due to RANKL Signaling and Reside in the Bronchiolar Epithelium Associated With iBALT in Murine Models of Respiratory Disease

気道M細胞は,呼吸器疾患のマウスモデルにおけるIbaltに関連したbronchikl上皮におけるRanklシグナル伝達による下部気道で生じる【JST・京大機械翻訳】

Author (12)： Kimura Shunsuke (Laboratory of Histology and Cytology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan) ,  Kimura Shunsuke (Division of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo, Japan) ,  Mutoh Mami (Department of Orthodontics, Faculty of Dental Medicine, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan) ,  Hisamoto Meri (Division of Oral Functional Science, Department of Oral Functional Prosthodontics, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan) ,  Saito Hikaru (School of Medicine, Hokkaido University, Sapporo, Japan) ,  Takahashi Shun (School of Medicine, Hokkaido University, Sapporo, Japan) ,  Asakura Takanori (Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Ishii Makoto (Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan) ,  Nakamura Yutaka (Division of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo, Japan) ,  Iida Junichiro (Department of Orthodontics, Faculty of Dental Medicine, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan) ,  Hase Koji (Division of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo, Japan) ,  Iwanaga Toshihiko (Laboratory of Histology and Cytology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan)
Material： Frontiers in Immunology (Web)
Volume： 10  Page： 1323  Publication year： 2019 
JST Material Number： U7074A  ISSN： 1664-3224  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Microfold (M) cells residing i...

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Thesaurus term： fluorescent antibody technique ,  NF-kappaB ,  RANKL ,  lymphoid tissue ,  trachea(animal organ) ,  *epithelium ,  mucosal immunity ,  glycoprotein ,  *air duct (respiration) ,  differentiation (biology) ,  autoimmune disease ,  Lymph ,  antigen ,  *mouse model ,  *M cells ,  bioassay ,  *membrane and film ,  *histomembrane ,  body fluid

Author keywords (6)： M cells ,  microfold cells ,  iBALT ,  GP2 ,  RANKL ,  lower airway

JST classification (3)： Infectious immunity  (ED03030P) ,  Biological function  (EB03040U) ,  Immunological reaction in general  (ED03010T)

Reference (45)：

• Hiemstra PS, McCray PB Jr., Bals R. The innate immune function of airway epithelial cells in inflammatory lung disease. Eur Respir J. (2015) 45:1150-62. doi: 10.1183/09031936.00141514
• Gao W, Li L, Wang Y, Zhang S, Adcock IM, Barnes PJ, et al. Bronchial epithelial cells: the key effector cells in the pathogenesis of chronic obstructive pulmonary disease? Respirology. (2015) 20:722-9. doi: 10.1111/resp.12542
• Pilette C, Ouadrhiri Y, Godding V, Vaerman JP, Sibille Y. Lung mucosal immunity: immunoglobulin-A revisited. Eur Respir J. (2001) 18:571-88. doi: 10.1111/resp.12542
• Neutra MR, Phillips TL, Mayer EL, Fishkind DJ. Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer's patch. Cell Tissue Res. (1987) 247:537-46. doi: 10.1111/resp.12542
• Bockman DE, Cooper MD. Pinocytosis by epithelium associated with lymphoid follicles in the bursa of Fabricius, appendix, and Peyer's patches. An electron microscopic study. Am J Anat. (1973) 136:455-77. doi: 10.1111/resp.12542

Terms in the title (7)： 気道 ,  M細胞 ,  呼吸器疾患 ,  マウスモデル ,  上皮 ,  RANKL ,  シグナル伝達