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J-GLOBAL ID：201902235307619701   Reference number：19A2084350

Antidepressant amitriptyline-induced matrix metalloproteinase-9 activation is mediated by Src family tyrosine kinase, which leads to glial cell line-derived neurotrophic factor mRNA expression in rat astroglial cells

抗うつ薬アミトリプチリン誘導マトリックスメタロプロテイナーゼ-9活性化は,ラット星状細胞においてグリア細胞株由来神経栄養因子のmRNA発現を誘導するSrcファミリーチロシンキナーゼによって仲介される

Author (8)： Abe Hiromi (Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Japan) ,  Abe Hiromi (Department of Pharmacy, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Japan) ,  Kajitani Naoto (Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Japan) ,  Okada-Tsuchioka Mami (Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Japan) ,  Omori Wataru (Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Japan) ,  Yatsumoto Masahide (Department of Pharmacy, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Japan) ,  Takebayashi Minoru (Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, Kure, Japan) ,  Takebayashi Minoru (Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan)
Material： Neuropsychopharmacology Reports (Web)
Volume： 39  Issue： 3  Page： 156-163  Publication year： 2019 
JST Material Number： U1387A  ISSN： 2574-173X  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *tricyclic antidepressive drug ,...
Semi thesaurus term： *Matrix Metalloproteinase 9 ,...

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Author keywords (5)： antidepressant ,  astrocyte ,  gelatin zymography ,  matrix metalloproteinase-9 ,  Src family tyrosine kinase

JST classification (1)： Basic research of psychotropic drugs  (GW03100Y)

Substance index (1)： Amitriptyline

Terms in the title (13)： 抗うつ薬 ,  アミトリプチリン ,  誘導 ,  マトリックスメタロプロテイナーゼ-9 ,  活性化 ,  ラット ,  星状細胞 ,  グリア細胞株由来神経栄養因子 ,  mRNA発現 ,  SRC ,  ファミリー ,  チロシンキナーゼ ,  仲介