Art

J-GLOBAL ID：201902235826533035   Reference number：19A1397599

Impact of depth filtration on disulfide bond reduction during downstream processing of monoclonal antibodies from CHO cell cultures

CHO細胞培養からのモノクローナル抗体の下流プロセシング中のジスルフィド結合還元に及ぼす深度濾過の影響【JST・京大機械翻訳】

Author (11)： O'Mara Brian (BioProcess Development, Bristol-Myers Squibb Co., Seattle, Washington) ,  Gao Zhong-Hua (BioProcess Development, Bristol-Myers Squibb Co., Seattle, Washington) ,  Kuruganti Manju (BioProcess Development, Bristol-Myers Squibb Co., Seattle, Washington) ,  Mallett Robert (BioProcess Development, Bristol-Myers Squibb Co., Seattle, Washington) ,  Nayar Gautam (BioProcess Development, Bristol-Myers Squibb Co., Seattle, Washington) ,  Smith Laura (BioProcess Development, Bristol-Myers Squibb Co., Seattle, Washington) ,  Meyer Jeffrey D. (BioProcess Development, Bristol-Myers Squibb Co., Seattle, Washington) ,  Therriault Jon (BioProcess Development, Bristol-Myers Squibb Co., Seattle, Washington) ,  Miller Cameron (BioProcess Development, Bristol-Myers Squibb Co., Seattle, Washington) ,  Cisney John (BioProcess Development, Bristol-Myers Squibb Co., Seattle, Washington) ,  Fann John (BioProcess Development, Bristol-Myers Squibb Co., Seattle, Washington)
Material： Biotechnology and Bioengineering  (Biotechnol Bioeng)
Volume： 116  Issue： 7  Page： 1669-1683  Publication year： 2019 
JST Material Number： D0019A  ISSN： 0006-3592  CODEN： BIBIAU  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Monoclonal antibody interchain...

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Thesaurus term： *disulfide bond ,  bioengineering ,  *antibody ,  *disulfide ,  phosphoric acid ,  centrifugal separation ,  *reduction(reaction) ,  *monoclonal antibody ,  *cell culture ,  characterization ,  dissolved oxygen ,  thioredoxin ,  continuum flow ,  thiol
Semi thesaurus term： 細胞溶解 , 【Automatic Indexing@JST】

Author keywords (7)： air overlay ,  antibody ,  cell lysis ,  depth filtration ,  differential pressure ,  dissolved oxygen ,  disulfide reduction

JST classification (3)： Production and application of antigens,antibodies,complements  (ED04030W) ,  Cell and tissue culture methods  (EA03040R) ,  Gene expression  (EC02040Q)

Terms in the title (9)： CHO細胞 ,  培養 ,  モノクローナル抗体 ,  下流 ,  プロセシング ,  ジスルフィド結合 ,  還元 ,  深度 ,  濾過