Art

J-GLOBAL ID：201902236424686738   Reference number：19A0481541

Tbx6 Is Critical for Mesoderm Induction and Lineage Diversification into Cardiovascular and Somite Lineages in Pluripotent Stem Cells

Tbx6は多能性幹細胞から中胚葉を誘導し,心血管系と筋骨格系への分化を制御する

Author (2)： SADAHIRO TAKETARO (筑波大 医学医療系 循環器内科) ,  IEDA MASAKI (筑波大 医学医療系 循環器内科)
Material： 再生医療  (日本再生医療学会雑誌)
Volume： 18  Issue： 1  Page： 60-67  Publication year： Feb. 20, 2019 
JST Material Number： L2776B  ISSN： 1347-7919  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *homeobox gene ,...
Semi thesaurus term： Mesp1 ,...

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JST classification (1)： Cell physiology in general  (EF02010S)

Reference (24)：

• Wamstad JA, Alexander JM, Truty RM, et al. Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell. 2012 ; 151 : 206-20.
• Paige SL, Thomas S, Stoick-Cooper CL, et al. A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell. 2012 ; 151 : 221-32.
• Loh KM, Chen A, Koh PW, et al. Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell. 2016 ; 166 : 451-67.
• Kattman SJ, Witty AD, Gagliardi M, et al. Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell. 2011 ; 8 : 228-40.
• Burridge PW, Matsa E, Shukla P, et al. Chemically defined generation of human cardiomyocytes. Nat Methods. 2014 ; 11 : 855-60.

Terms in the title (7)： Tbx6 ,  多能性幹細胞 ,  中胚葉 ,  誘導 ,  心血管系 ,  筋骨格系 ,  分化