Art

J-GLOBAL ID：201902236494331640   Reference number：19A2359948

A- and D-Ring Structural Modifications of an Androsterone Derivative Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3: Chemical Synthesis and Structure-Activity Relationships

17β-ヒドロキシステロイドデヒドロゲナーゼ3型を阻害するアンドロステロン誘導体のA-及びD-環構造修飾 化学合成及び構造活性相関【JST・京大機械翻訳】

Author (8)： Cortes-Benitez Francisco (Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Quebec-Research Center, Quebec, Canada) ,  Cortes-Benitez Francisco (Department of Biological Systems, Biological and Health Sciences Division, Metropolitan Autonomous University-Campus Xochimilco (UAM-X), Mexico) ,  Cortes-Benitez Francisco (Department of Pharmacy, Faculty of Chemistry, National Autonomous University of Mexico, Mexico) ,  Roy Jenny (Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Quebec-Research Center, Quebec, Canada) ,  Perreault Martin (Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Quebec-Research Center, Quebec, Canada) ,  Maltais Rene (Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Quebec-Research Center, Quebec, Canada) ,  Poirier Donald (Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Quebec-Research Center, Quebec, Canada) ,  Poirier Donald (Department of Molecular Medicine, Faculty of Medicine, Universite Laval, Quebec, Canada)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 62  Issue： 15  Page： 7070-7088  Publication year： 2019 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Decreasing the intratumoral an...

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Thesaurus term： characterization ,  prostatic tumor ,  plasma concentration ,  male sex hormone ,  *Structure-Activity Relationship ,  Cell Proliferation ,  diversification ,  *chemical synthesis ,  biosynthesis ,  Mus musculus ,  lead compound ,  inhibitory activity ,  *17beta-hydroxysteroid dehydrogenase ,  Myomorpha ,  steroid ,  alicyclic alcohol ,  alicyclic ketone ,  secondary alcohol
Semi thesaurus term： 阻害剤 , 【Automatic Indexing@JST】

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Physicochemical pharmacy in general  (GV01010J)

Substance index (1)： Androsterone

Terms in the title (8)： 17β-ヒドロキシステロイドデヒドロゲナーゼ ,  阻害 ,  アンドロステロン ,  誘導体 ,  環構造 ,  修飾 ,  化学合成 ,  構造活性相関