Art

J-GLOBAL ID：201902236530033241   Reference number：19A1323944

Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines

メトホルミンは肝細胞癌細胞株におけるAMPK-CEBPβ経路を介してCD133の発現を調節する【JST・京大機械翻訳】

Author (9)： Maehara Osamu (Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Ohnishi Shunsuke (Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan) ,  Asano Ayaka (Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Suda Goki (Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan) ,  Natsuizaka Mitsuteru (Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan) ,  Nakagawa Koji (Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan) ,  Kobayashi Masanobu (Department of Nursing, Health Sciences University of Hokkaido, Tobetsu, Japan) ,  Sakamoto Naoya (Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan) ,  Takeda Hiroshi (Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan)
Material： Neoplasia
Volume： 21  Issue： 6  Page： 545-556  Publication year： 2019 
JST Material Number： W3158A  ISSN： 1476-5586  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： CD133 is a cellular surface pr...

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Thesaurus term： culture (biology) ,  combined effect ,  Carcinogenesis ,  Diabetes Mellitus ,  *hepatocyte ,  drug sensitivity ,  Proteins ,  promoter (genetics) ,  gene expression ,  protein kinase ,  overexpression ,  isoform ,  *CD133 antigen ,  molecular genetic phenomenon ,  ether ,  macrocyclic compound ,  lactam ,  lactone ,  enzyme inhibitor ,  hemiacetal ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy ketone ,  aliphatic amine

JST classification (1)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (2)： Sirolimus ,  Metformin

Terms in the title (8)： メトホルミン ,  肝細胞癌 ,  細胞株 ,  AMPK ,  経路 ,  CD133 ,  発現 ,  調節