Art

J-GLOBAL ID：201902236705087308   Reference number：19A0885636

Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy

イデベノン: その全身および局所効果を改善するための新規戦略【JST・京大機械翻訳】

Author (4)： Montenegro Lucia (Department of Drug Sciences, Pharmaceutical Technology Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy) ,  Turnaturi Rita (Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy) ,  Parenti Carmela (Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy) ,  Pasquinucci Lorella (Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy)
Material： Nanomaterials (Web)
Volume： 8  Issue： 2  Page： 87  Publication year： 2018 
JST Material Number： U7252A  ISSN： 2079-4991  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The key role of antioxidants i...

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Thesaurus term： drug delivery system ,  bioavailability ,  enzyme ,  locality ,  effectiveness ,  water solubility ,  emulsification ,  cosmetic ,  liposome ,  *nano particle ,  local administration ,  cyclodextrin ,  antioxidant ,  antioxidants ,  thin film ,  bilayer ,  lipid membrane ,  layer ,  multilayer (molecule) ,  multilayer ,  lipid bilayer membrane ,  alcohol ,  quinone ,  alicyclic compound ,  diene ,  enol ether

Author keywords (5)： idebenone ,  delivery systems ,  nanocarriers ,  idebenone analogues ,  neurodegenerative diseases

JST classification (2)： Medical materials  (GA05040H) ,  Gene manipulation  (EC02050B)

Substance index (1)： Idebenone

Reference (104)：

• Meier, T.; Buyse, G. Idebenone: An emerging therapy for Friedreich ataxia. J. Neurol. 2009, 256, 25-30.
• El-Hattab, A.W.; Zarante, A.M.; Almannai, M.; Scaglia, F. Therapies for mitochondrial diseases and current clinical trials. Mol. Genet. Metab. 2017, 122, 1-9.
• Erb, M.; Hoffmann-Enger, B.; Deppe, H.; Soeberdt, M.; Haefeli, R.H.; Rummey, C.; Feurer, A.; Gueven, N. Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I. PLoS ONE 2012, 7, e36153.
• Jaber, S.; Polster, B.M. Idebenone and Neuroprotection: Antioxidant, Pro-oxidant, or Electron Carrier? J. Bioenerg. Biomembr. 2015, 47, 111-118.
• Zhang, Z.W.; Xu, X.C.; Liu, T.; Yuan, S. Mitochondrion-permeable antioxidants to treat ROS-burst-mediated acute diseases. Oxidative Med. Cell. Longev. 2016, 2016, 6859523.

Terms in the title (3)： イデベノン ,  全身 ,  戦略