Art

J-GLOBAL ID：201902236927610303   Reference number：19A1206965

Distinct mutation spectrum, clinical outcome and therapeutic responses of typical complex/monosomy karyotype acute myeloid leukemia carrying TP53 mutations

TP53変異を持つ典型的な複合体/モノソミー核型急性骨髄性白血病の異なる変異スペクトル,臨床転帰および治療反応【JST・京大機械翻訳】

Author (24)： Leung Garret M. K. (Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China) ,  Zhang Chunxiao (Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China) ,  Ng Nelson K. L. (Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China) ,  Yang Ning (Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China) ,  Lam Stephen S. Y. (Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China) ,  Au Chun H. (Department of Pathology, Hong Kong Sanatorium and Hospital, Hong Kong, China) ,  Chan Tsun L. (Department of Pathology, Hong Kong Sanatorium and Hospital, Hong Kong, China) ,  Ma Edmond S. K. (Department of Pathology, Hong Kong Sanatorium and Hospital, Hong Kong, China) ,  Tsui Sze P. (Division of Haematology, Department of Pathology, Queen Mary Hospital, Hong Kong, China) ,  Ip Ho W. (Division of Haematology, Department of Pathology, Queen Mary Hospital, Hong Kong, China) ,  So Jason C. C. (Division of Haematology, Department of Pathology, Queen Mary Hospital, Hong Kong, China) ,  Ng Margaret H. L. (Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China) ,  Cheng Kelvin C. K. (Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China) ,  Wong Kit F. (Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China) ,  Siu Lisa L. P. (Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China) ,  Yip Sze F. (Department of Medicine, Tuen Mun Hospital, Hong Kong, China) ,  Lin Shek Y. (Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China) ,  Lau June S. M. (Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China) ,  Luk Tsan H. (Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China) ,  Lee Harold K. K. (Department of Medicine, Princess Margaret Hospital, Hong Kong, China) ,  Lau Chi K. (Department of Medicine, Tseung Kwan O Hospital, Hong Kong, China) ,  Kho Bonnie (Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China) ,  Kwong Yok L. (Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China) ,  Leung Anskar Y. H. (Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China)
Material： American Journal of Hematology  (Am J Hematol)
Volume： 94  Issue： 6  Page： 650-657  Publication year： 2019 
JST Material Number： E0721B  ISSN： 0361-8609  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The present study aimed to def...

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Thesaurus term： *Bone Marrow ,  Mutation ,  gene ,  sensitivity ,  clinical trial ,  p53 protein ,  survival ratio ,  *complex (substance) ,  *acute myeloid leukemia ,  targeting ,  *TP53 ,  *Genetic Variation ,  alicyclic compound ,  lactone ,  enzyme inhibitor ,  phenolic compound ,  glycoside (except carbohydrate) ,  olefin compound ,  pyranoside ,  glucoside ,  phenol ether ,  polynuclear aromatic compound
Semi thesaurus term： *variation(biology) ,  同種造血幹細胞移植 ,  サブタイプ , 【Automatic Indexing@JST】

JST classification (1)： Blood cell tumors(=neoplasms)  (GK04000M)

Substance index (1)： Etoposide

Terms in the title (9)： TP53 ,  変異 ,  複合体 ,  モノソミー ,  核型 ,  急性骨髄性白血病 ,  スペクトル ,  臨床転帰 ,  治療反応