Art

J-GLOBAL ID：201902239946301742   Reference number：19A1861499

Growth Inhibition of Human Breast and Prostate Cancer Cells by Cinnamic Acid Derivatives and Their Mechanism of Action

桂皮酸誘導体によるヒト乳癌および前立腺癌細胞の増殖阻害とその作用機序

Author (4)： Imai Masahiko (Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University) ,  Yokoe Hiromasa (Laboratory of Bioorganic Chemistry, Institute of Medicinal Chemistry, Hoshi University) ,  Tsubuki Masayoshi (Laboratory of Bioorganic Chemistry, Institute of Medicinal Chemistry, Hoshi University) ,  Takahashi Noriko (Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 7  Page： 1134-1139(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： cell growth inhibition

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Author keywords (10)： cinnamic acid ,  caffeic acid phenethyl ester ,  breast cancer ,  prostate cancer ,  apoptosis ,  cinnamic acid ,  caffeic acid phenethyl ester ,  breast cancer ,  prostate cancer ,  apoptosis

JST classification (3)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (2)： Phenethyl caffeate ,  3,4,5-トリヒドロキシけい皮酸デシル

Reference (14)：

• 1) Chen YJ, Shiao MS, Wang SY. The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells. Anticancer Drugs, 12, 143-149 (2001).
• 2) Orban Z, Mitsiades N, Burke TR Jr, Tsokos M, Chrousos GP. Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation. Neuroimmunomodulation, 7, 99-105 (2000).
• 3) Fesen MR, Kohn KW, Leteurtre F, Pommier Y. Inhibitors of human immunodeficiency virus integrase. Proc. Natl. Acad. Sci. U.S.A., 90, 2399-2403 (1993).
• 4) Lefkovits I, Su Z, Fisher P, Grunberger D. Caffeic acid phenethyl ester profoundly modifies protein synthesis profile in type 5 adenovirus-transformed cloned rat embryo fibroblast cells. Int. J. Oncol., 11, 59-67 (1997).
• 5) Sud’ina GF, Mirzoeva OK, Pushkareva MA, Korshunova GA, Sumbatyan NV, Varfolomeev SD. Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett., 329, 21-24 (1993).

Terms in the title (6)： 桂皮酸誘導体 ,  ヒト ,  乳癌 ,  前立腺癌細胞 ,  増殖阻害 ,  作用機序